Linked Life Data

12794123

Source:http://linkedlifedata.com/resource/pubmed/id/12794123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2003-6-9
pubmed:abstractText
HIV infection leads to numerous immunologic defects, including impaired B cell function. An effective humoral response requires bidirectional interactions between B cells and CD4(+) T cells, critical of which are interactions between CD80/CD86 expressed on activated B cells and CD28 expressed on responder CD4(+) T cells. In the present study, we examined the effect of active HIV replication on B cell costimulatory function. Induction of CD80/CD86 on B cells following B cell receptor and CD40 triggering and responsiveness of CD4(+) T cells to activated B cells were investigated in a system where B cells of HIV-infected patients were compared concurrently to B cells of HIV-negative donors. In contrast to HIV-aviremic patients, B cells of HIV-viremic patients were ineffective at stimulating CD4(+) T cells, as measured by the induction of activation markers and proliferation. The importance of interactions of CD80/CD86 and CD28 in activating CD4(+) T cells was clear; the ablation of a normal response following the addition of neutralizing anti-CD86/CD80 Abs mirrored the response of CD4(+) T cells to B cells of HIV-viremic patients, while the addition of exogenous CD28 ligands partially restored the poor CD4(+) T cell response to the B cells of HIV-viremic patients. Ineffective B cell costimulatory function in HIV-viremic patients was associated with low induction of CD80/CD86 expression on B cells. Our findings further delineate the scope of defects associated with cognate B cell-CD4(+) T cell interactions in HIV infection and suggest that therapeutic interventions designed to enhance CD28-dependent costimulatory pathways may help restore immune functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5965-72
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:12794123-Antigens, CD, pubmed-meshheading:12794123-Antigens, CD40, pubmed-meshheading:12794123-Antigens, CD80, pubmed-meshheading:12794123-Antigens, CD86, pubmed-meshheading:12794123-B-Lymphocyte Subsets, pubmed-meshheading:12794123-CD4-Positive T-Lymphocytes, pubmed-meshheading:12794123-Cell Communication, pubmed-meshheading:12794123-Cell Division, pubmed-meshheading:12794123-Cells, Cultured, pubmed-meshheading:12794123-Cross-Sectional Studies, pubmed-meshheading:12794123-Down-Regulation, pubmed-meshheading:12794123-HIV Infections, pubmed-meshheading:12794123-HIV-1, pubmed-meshheading:12794123-Humans, pubmed-meshheading:12794123-Immune Tolerance, pubmed-meshheading:12794123-Longitudinal Studies, pubmed-meshheading:12794123-Lymphocyte Activation, pubmed-meshheading:12794123-Membrane Glycoproteins, pubmed-meshheading:12794123-RNA, Viral, pubmed-meshheading:12794123-Receptors, Antigen, B-Cell, pubmed-meshheading:12794123-Viremia, pubmed-meshheading:12794123-Virus Replication
pubmed:year
2003
pubmed:articleTitle
Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function.
pubmed:affiliation
Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType
Journal Article