Source:http://linkedlifedata.com/resource/pubmed/id/12793998
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-6-9
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| pubmed:abstractText |
Stage 2 sleep is characterized by the EEG appearance of "K-complexes" and blood pressure oscillations. K-complexes may be directly related to blood pressure changes or they may reflect central sympathetic activation. We analyzed the temporal relationship among K-complexes, heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) during sleep in eight healthy volunteers (3 men and 5 women, age 22-41 yr). Most K-complexes presented as single large complexes (56 +/- 20%), followed by single small complexes (15 +/- 14%) and as couplets or triplets (13 +/- 6%). Single large K-complexes were preceded by a baroreflex-mediated increase of MSNA in approximately one-half (55%) of the cases. Detailed analysis of HR, BP, and MSNA was possible in 63 (45%) large single K-complexes not disturbed by preceding baroreflex-related changes. Systolic and diastolic BP and MSNA increased significantly after single events (22.5 +/- 13, 5.2 +/- 2.1, and 6.5 +/- 3.0%). Mean sympathetic baroreflex latency was similar after the single large K-complexes compared with the mean value during stage 2 sleep (1,290 +/- 126 vs. 1,279 +/- 61 ms). The area under the burst was significantly increased after single large K-complexes (median 3.9 vs. 9.0 arbitrary units, P < 0.03). The results support the hypothesis that K-complexes express cortical activation leading to temporary facilitation of sympathetic outflow in a graded fashion. Their functional effects appear to be independent of baroreflex modulation of MSNA in approximately 50% of the cases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0363-6119
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
285
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
R208-14
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12793998-Adult,
pubmed-meshheading:12793998-Baroreflex,
pubmed-meshheading:12793998-Blood Pressure,
pubmed-meshheading:12793998-Electrocardiography,
pubmed-meshheading:12793998-Electroencephalography,
pubmed-meshheading:12793998-Female,
pubmed-meshheading:12793998-Heart Rate,
pubmed-meshheading:12793998-Humans,
pubmed-meshheading:12793998-Male,
pubmed-meshheading:12793998-Muscle, Skeletal,
pubmed-meshheading:12793998-Reaction Time,
pubmed-meshheading:12793998-Sleep Stages,
pubmed-meshheading:12793998-Sympathetic Nervous System
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| pubmed:year |
2003
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| pubmed:articleTitle |
Relationship between blood pressure, sleep K-complexes, and muscle sympathetic nerve activity in humans.
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| pubmed:affiliation |
Helios Klinikum Berlin, Clinical Research Center, Franz Volhard Clinic, Charité Campus-Buch, Humboldt Univ. Berlin, Wiltberg Str. 50, 13125 Berlin, Germany. tank@fvk-berlin.de
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| pubmed:publicationType |
Journal Article
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