| pubmed-article:12792355 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12792355 | lifeskim:mentions | umls-concept:C0042960 | lld:lifeskim |
| pubmed-article:12792355 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12792355 | lifeskim:mentions | umls-concept:C1549078 | lld:lifeskim |
| pubmed-article:12792355 | lifeskim:mentions | umls-concept:C1997894 | lld:lifeskim |
| pubmed-article:12792355 | lifeskim:mentions | umls-concept:C0079600 | lld:lifeskim |
| pubmed-article:12792355 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12792355 | pubmed:dateCreated | 2003-6-6 | lld:pubmed |
| pubmed-article:12792355 | pubmed:abstractText | We analyzed the epitopes and the molecular forms of Tat recognized by the antibodies raised by Tat-toxoid vaccination in both healthy and HIV-infected volunteers. Tat-toxoid-vaccinated healthy volunteer sera reacted predominantly with peptides covering amino acids 1 through 24 and 46 through 60, corresponding to the N-terminus and basic domains of Tat. In contrast, whereas all sera from vaccinated HIV-1-positive patients reacted with the N-terminus and (with a single exception) with the basic domain, most of these sera also recognized peptides encompassing distinct domains of Tat, particularly the C-terminus (79-86). The sera of vaccinated individuals recognized both monomeric and oligomeric forms of Tat 1 through 86 or of Tat 1 through 101 and also blocked the ability of cell-released extracellular Tat to transactivate the HIV-1 LTR promoter. Synthetic Tat preincubated with sera from vaccinated individuals lost its functional activity as well. This is probably because of its inability to enter the cells as a result of immune complex formation with anti-Tat IgG. These data demonstrate that Tat-toxoid vaccination induces an efficient antibody response blocking the functional activity of Tat. | lld:pubmed |
| pubmed-article:12792355 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12792355 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792355 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12792355 | pubmed:month | May | lld:pubmed |
| pubmed-article:12792355 | pubmed:issn | 1525-4135 | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:AlbiniAdriana... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:NoonanDouglas... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:FerriniSilvan... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:MeazzaRaffael... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:GringeriAless... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:RossoOmbretta... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:AccollaRobert... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:MazzaStefania... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:Muça-PerjaMyr... | lld:pubmed |
| pubmed-article:12792355 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:12792355 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12792355 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12792355 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12792355 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12792355 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12792355 | pubmed:pagination | 47-55 | lld:pubmed |
| pubmed-article:12792355 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
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| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
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| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:meshHeading | pubmed-meshheading:12792355... | lld:pubmed |
| pubmed-article:12792355 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12792355 | pubmed:articleTitle | Identification of immunodominant epitopes in inactivated Tat-vaccinated healthy and HIV-1-infected volunteers. | lld:pubmed |
| pubmed-article:12792355 | pubmed:affiliation | Tumor Progression Section, double dagger Immuno-Pharmacology Section, and #Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. | lld:pubmed |
| pubmed-article:12792355 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12792355 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12792355 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12792355 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12792355 | lld:pubmed |
