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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5625
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pubmed:dateCreated |
2003-6-6
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pubmed:abstractText |
Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MYD88 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NOD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NOD2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nod1 Signaling Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nod2 Signaling Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidoglycan,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Trisaccharides
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:AntignacAudeA,
pubmed-author:BertinJohnJ,
pubmed-author:BonecaIvo GIG,
pubmed-author:CarneiroLeticia A MLA,
pubmed-author:CoyleAnthony JAJ,
pubmed-author:DiStefanoPeter SPS,
pubmed-author:GirardinStephen ESE,
pubmed-author:JéhannoMuguetteM,
pubmed-author:LabigneAgnesA,
pubmed-author:PhilpottDana JDJ,
pubmed-author:SansonettiPhilippe JPJ,
pubmed-author:TahaMuhamed-KheirMK,
pubmed-author:TedinKarstenK,
pubmed-author:VialaJérômeJ,
pubmed-author:ZähringerUlrichU
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1584-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12791997-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12791997-Amino Acid Motifs,
pubmed-meshheading:12791997-Animals,
pubmed-meshheading:12791997-Antigens, Differentiation,
pubmed-meshheading:12791997-Carrier Proteins,
pubmed-meshheading:12791997-Cell Line,
pubmed-meshheading:12791997-Cytoplasm,
pubmed-meshheading:12791997-Epithelial Cells,
pubmed-meshheading:12791997-Gram-Negative Bacteria,
pubmed-meshheading:12791997-Gram-Positive Bacteria,
pubmed-meshheading:12791997-Humans,
pubmed-meshheading:12791997-Immunity, Innate,
pubmed-meshheading:12791997-Interleukin-8,
pubmed-meshheading:12791997-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12791997-Lipopolysaccharides,
pubmed-meshheading:12791997-Mice,
pubmed-meshheading:12791997-Myeloid Differentiation Factor 88,
pubmed-meshheading:12791997-NF-kappa B,
pubmed-meshheading:12791997-Nod1 Signaling Adaptor Protein,
pubmed-meshheading:12791997-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:12791997-Oligopeptides,
pubmed-meshheading:12791997-Peptidoglycan,
pubmed-meshheading:12791997-Protein Structure, Tertiary,
pubmed-meshheading:12791997-Receptors, Immunologic,
pubmed-meshheading:12791997-Signal Transduction,
pubmed-meshheading:12791997-Trisaccharides
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pubmed:year |
2003
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pubmed:articleTitle |
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.
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pubmed:affiliation |
Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, 28, Rue du Dr. Roux, 75724Paris Cedex 15, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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