| pubmed-article:12791677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12791677 | lifeskim:mentions | umls-concept:C0225700 | lld:lifeskim |
| pubmed-article:12791677 | lifeskim:mentions | umls-concept:C0070099 | lld:lifeskim |
| pubmed-article:12791677 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12791677 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12791677 | pubmed:dateCreated | 2003-11-20 | lld:pubmed |
| pubmed-article:12791677 | pubmed:abstractText | Parathyroid hormone-related protein (PTHrP) promotes or suppresses apoptosis in various settings depending on cell type and context. PTHrP 1-34 and PTHrP 67-86 are type II cell growth factors with effects on pneumocyte growth and surfactant secretion. This study investigated the effects of 24 h pretreatment with these two peptides on rat type II cell apoptosis after 0.3 J/cm2 ultraviolet-B irradiation. Adherent cells decreased in number by 15 +/- 5% and nonadherent cells increased > 5-fold 24 h after ultraviolet irradiation. Cell loss was due predominantly to apoptosis, based on ethidium bromide exclusion, nuclear condensation, and caspase 3 activity. Nuclear condensation increased from 15.6 +/- 2.2% of irradiated cells with no treatment to 25.6 +/- 4.9 and 22.9 +/- 1.8% of cells in ultraviolet/PTHrP 1-34 and ultraviolet/PTHrP 67-86 groups, respectively (P < 0.01), along with a 60% increase in caspase 3 activity. Effects on apoptosis were unaffected by the presence or absence of serum, but were ameliorated by growth to confluence or adherence to fibronectin. PTHrP 1-34 and PTHrP 67-86 augmented inositol phosphate levels, but had minimal effects on cAMP. Thus, PTHrP 1-34 and PTHrP 67-86 sensitize type II cells to apoptosis, possibly by a phospholipase C-dependent mechanism. The effects appear to be regulated by cell-matrix and cell-cell interactions. | lld:pubmed |
| pubmed-article:12791677 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12791677 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12791677 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12791677 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:BurtonDouglas... | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:DeftosLeonard... | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:HastingsRando... | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:SandovalRebec... | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:QuintanaRick... | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:DueyDevinD | lld:pubmed |
| pubmed-article:12791677 | pubmed:author | pubmed-author:RasconYvetteY | lld:pubmed |
| pubmed-article:12791677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12791677 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:12791677 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12791677 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12791677 | pubmed:pagination | 733-42 | lld:pubmed |
| pubmed-article:12791677 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:meshHeading | pubmed-meshheading:12791677... | lld:pubmed |
| pubmed-article:12791677 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12791677 | pubmed:articleTitle | Proapoptotic effects of parathyroid hormone-related protein in type II pneumocytes. | lld:pubmed |
| pubmed-article:12791677 | pubmed:affiliation | VA Medical Center (125), 3350 La Jolla Village Dr., San Diego, CA 92161-5085, USA. rhhastings@ucsd.edu | lld:pubmed |
| pubmed-article:12791677 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12791677 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12791677 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12791677 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12791677 | lld:pubmed |
