| pubmed-article:12791661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C1883036 | lld:lifeskim |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12791661 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12791661 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12791661 | pubmed:dateCreated | 2003-9-23 | lld:pubmed |
| pubmed-article:12791661 | pubmed:abstractText | Apoptosis or programmed cell death plays an important role in a wide variety of physiologic processes and is regulated by proteins of the Bcl-2 family consisting of both antiapoptotic and proapoptotic factors. The direct involvement of the Bcl-2 protein family in the process of mast cell apoptosis has not been clarified. In the present work we have used a single-chain antibody (scFv) raised against Bcl-2 derived from a semisynthetic human phage-display antibody library. The addition of TAT sequence, which is responsible for translocation through the membrane, endows the anti-Bcl-2-scFv with the ability to penetrate living cells. Moreover, it specifically neutralizes Bcl-2 intracellularly by binding to the BH1 domain and eradicates its antiapoptotic activity in 2 types of mast cells and in a human breast cancer cell line. | lld:pubmed |
| pubmed-article:12791661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12791661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12791661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12791661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12791661 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12791661 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12791661 | pubmed:author | pubmed-author:NechushtanHov... | lld:pubmed |
| pubmed-article:12791661 | pubmed:author | pubmed-author:RazinEhudE | lld:pubmed |
| pubmed-article:12791661 | pubmed:author | pubmed-author:NissimAhuvaA | lld:pubmed |
| pubmed-article:12791661 | pubmed:author | pubmed-author:Cohen-SaidonC... | lld:pubmed |
| pubmed-article:12791661 | pubmed:author | pubmed-author:KahlonShiraS | lld:pubmed |
| pubmed-article:12791661 | pubmed:author | pubmed-author:LivniNadavN | lld:pubmed |
| pubmed-article:12791661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12791661 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12791661 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:12791661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12791661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12791661 | pubmed:pagination | 2506-12 | lld:pubmed |
| pubmed-article:12791661 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12791661 | pubmed:meshHeading | pubmed-meshheading:12791661... | lld:pubmed |
| pubmed-article:12791661 | pubmed:meshHeading | pubmed-meshheading:12791661... | lld:pubmed |
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| pubmed-article:12791661 | pubmed:meshHeading | pubmed-meshheading:12791661... | lld:pubmed |
| pubmed-article:12791661 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12791661 | pubmed:articleTitle | A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival. | lld:pubmed |
| pubmed-article:12791661 | pubmed:affiliation | Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:12791661 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12791661 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12791661 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12791661 | lld:pubmed |
