Linked Life Data

12791315

Source:http://linkedlifedata.com/resource/pubmed/id/12791315

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SubjectPredicateObjectContext
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pubmed-article:12791315pubmed:abstractTextAutoimmune-prone mice bear a hyper-active B cell population generated spontaneously in peripheral lymphoid organs. Expression of beta RNA-primase GANP was shown to be an activation marker in lymphoid follicle germinal center (GC) B cells after immunization with T cell-dependent antigen (TD-Ag) in normal mice. In this study, we examined the expression of GANP in lymphoid tissues of autoimmune-prone mice. GANP expression was up-regulated in GC-B cells after stimulation with TD-Ags; however, highly GANP-positive (GANP(hi)) cells were also observed in lymph nodes of non-immunized MRL/lpr mice. GANP(hi)cells in lymph nodes as well as in spleens of the different autoimmune-prone strains, MRL/lpr, NZB, (NZBxNZW)F1 and BXSB, gradually increased with age. This population was detected only in small numbers in the red pulp region of the spleen after immunization with TD-Ag in normal C57BL/6 and BALB/c mice. GANP(hi)cells had a B220(-)IgM(+)Syndecan-1(+)phenotype, but were negative for PAS-staining and bromo-deoxyuridine incorporation. These results demonstrate that GANP(hi)plasma-like cells appear in lymph nodes of autoimmune mice during aging, suggesting that the new plasma cell population might be generated after hyper-activation of B cells during the course of autoimmune disease.lld:pubmed
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pubmed-article:12791315pubmed:authorpubmed-author:SakaguchiNobu...lld:pubmed
pubmed-article:12791315pubmed:authorpubmed-author:TomitaKimioKlld:pubmed
pubmed-article:12791315pubmed:authorpubmed-author:HiroseSachiko...lld:pubmed
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pubmed-article:12791315pubmed:pagination291-301lld:pubmed
pubmed-article:12791315pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12791315pubmed:year2003lld:pubmed
pubmed-article:12791315pubmed:articleTitleSpontaneous increase of plasma-like cells with high GANP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice.lld:pubmed
pubmed-article:12791315pubmed:affiliationDepartment of Immunology, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860-0811, Japan.lld:pubmed
pubmed-article:12791315pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12791315pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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