Source:http://linkedlifedata.com/resource/pubmed/id/12791315
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-6-6
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| pubmed:abstractText |
Autoimmune-prone mice bear a hyper-active B cell population generated spontaneously in peripheral lymphoid organs. Expression of beta RNA-primase GANP was shown to be an activation marker in lymphoid follicle germinal center (GC) B cells after immunization with T cell-dependent antigen (TD-Ag) in normal mice. In this study, we examined the expression of GANP in lymphoid tissues of autoimmune-prone mice. GANP expression was up-regulated in GC-B cells after stimulation with TD-Ags; however, highly GANP-positive (GANP(hi)) cells were also observed in lymph nodes of non-immunized MRL/lpr mice. GANP(hi)cells in lymph nodes as well as in spleens of the different autoimmune-prone strains, MRL/lpr, NZB, (NZBxNZW)F1 and BXSB, gradually increased with age. This population was detected only in small numbers in the red pulp region of the spleen after immunization with TD-Ag in normal C57BL/6 and BALB/c mice. GANP(hi)cells had a B220(-)IgM(+)Syndecan-1(+)phenotype, but were negative for PAS-staining and bromo-deoxyuridine incorporation. These results demonstrate that GANP(hi)plasma-like cells appear in lymph nodes of autoimmune mice during aging, suggesting that the new plasma cell population might be generated after hyper-activation of B cells during the course of autoimmune disease.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0896-8411
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
20
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
291-301
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12791315-Animals,
pubmed-meshheading:12791315-Antigens,
pubmed-meshheading:12791315-Autoimmune Diseases,
pubmed-meshheading:12791315-Autoimmunity,
pubmed-meshheading:12791315-B-Lymphocytes,
pubmed-meshheading:12791315-Female,
pubmed-meshheading:12791315-Germinal Center,
pubmed-meshheading:12791315-Immunization,
pubmed-meshheading:12791315-Lymphocyte Activation,
pubmed-meshheading:12791315-Lymphoid Tissue,
pubmed-meshheading:12791315-Mice,
pubmed-meshheading:12791315-Mice, Inbred MRL lpr,
pubmed-meshheading:12791315-Mice, Inbred Strains,
pubmed-meshheading:12791315-Mice, Mutant Strains,
pubmed-meshheading:12791315-Nuclear Proteins,
pubmed-meshheading:12791315-Phosphoproteins,
pubmed-meshheading:12791315-Plasma Cells,
pubmed-meshheading:12791315-Time Factors
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Spontaneous increase of plasma-like cells with high GANP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice.
|
| pubmed:affiliation |
Department of Immunology, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860-0811, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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