Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-6-6
pubmed:abstractText
The aim of the study was to assess the association between promoter polymorphism [A(-596)G] in interleukin-6 gene and office systolic and diastolic blood pressures, and the heart rate (HR) in apparently healthy Czech subjects. Furthermore, we evaluated the possible influence of gender, BMI and smoking on these supposed associations. An age-matched (40-50 years) and gender-matched (F/M=81/89) sample of apparently healthy Czech subjects (n=170, F/M=81/89) without hypertension, other cardiovascular diseases or diabetes was examined. The A(-596)G Il-6 gene polymorphism was detected by the PCR method. No differences in genotype distribution and/or allelic frequency was found between groups with lower systolic blood pressure (? 122 mm Hg) and higher systolic blood pressure (> 122 mm Hg). Similarly, no differences in the IL-6 polymorphism were found between lower (? 86 mm Hg) and higher (> 86 mm Hg) diastolic blood pressure groups. However, we proved a significant increase of genotypes AG+GG as well as the allele (-596)G in higher (>78 beats/min) heart rate group. The genotypes AG+GG represent significantly higher relative risk for higher HR frequency, especially in women. Among lean persons with a low heart rate frequency, fewer AG+GG genotypes were determined than among any other subjects. The genotypes AG+GG are more frequent in non-smoking persons with higher HR compared to non-smoking subjects with lower HR, especially in women. Gender, BMI and smoking substantially modify the distribution of A(-596)G Il-6 gene polymorphism in apparently healthy persons with lower or higher heart rate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0862-8408
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12790760-Adult, pubmed-meshheading:12790760-Alleles, pubmed-meshheading:12790760-Blood Pressure, pubmed-meshheading:12790760-Body Mass Index, pubmed-meshheading:12790760-Czech Republic, pubmed-meshheading:12790760-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:12790760-Female, pubmed-meshheading:12790760-Gene Frequency, pubmed-meshheading:12790760-Genotype, pubmed-meshheading:12790760-Heart Rate, pubmed-meshheading:12790760-Humans, pubmed-meshheading:12790760-Interleukin-6, pubmed-meshheading:12790760-Male, pubmed-meshheading:12790760-Middle Aged, pubmed-meshheading:12790760-Polymerase Chain Reaction, pubmed-meshheading:12790760-Polymorphism, Genetic, pubmed-meshheading:12790760-Promoter Regions, Genetic, pubmed-meshheading:12790760-Sex Factors, pubmed-meshheading:12790760-Smoking
pubmed:year
2003
pubmed:articleTitle
Office blood pressure, heart rate and A(-596)G interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population.
pubmed:affiliation
Institute of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. avasku@med.muni.cz
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't