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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2003-6-5
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pubmed:abstractText |
The signal transducing protein Stat3 activates gene transcription in cells in response to multiple cytokines. Constitutive activation of Stat3 has been observed in solid tumors including head and neck squamous cell carcinoma. Stat3 activation in cancer has been associated with autocrine stimulatory loops and is believed to convey a growth advantage to cells. We now demonstrate ligand-independent activation of Stat3 by high cell density in multiple cancer cell lines. Activation of Stat3 is associated with antiproliferative rather than proliferative conditions. Interference with cdk2 activity upregulates Stat3 phosphorylation and Stat3-directed DNA-binding activity. Our data supports a model in which Stat3 activity is partially suppressed by cdk2 in growing cells and derepressed upon cell confluence.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/CDK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/rac1 GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/roscovitine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3608-15
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12789269-3T3 Cells,
pubmed-meshheading:12789269-Animals,
pubmed-meshheading:12789269-CDC2-CDC28 Kinases,
pubmed-meshheading:12789269-Carcinoma, Squamous Cell,
pubmed-meshheading:12789269-Cell Communication,
pubmed-meshheading:12789269-Cell Division,
pubmed-meshheading:12789269-Cyclin-Dependent Kinase 2,
pubmed-meshheading:12789269-Cyclin-Dependent Kinases,
pubmed-meshheading:12789269-DNA-Binding Proteins,
pubmed-meshheading:12789269-Enzyme Inhibitors,
pubmed-meshheading:12789269-Fibroblasts,
pubmed-meshheading:12789269-Head and Neck Neoplasms,
pubmed-meshheading:12789269-Humans,
pubmed-meshheading:12789269-Mice,
pubmed-meshheading:12789269-Mice, Knockout,
pubmed-meshheading:12789269-Phosphorylation,
pubmed-meshheading:12789269-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12789269-Purines,
pubmed-meshheading:12789269-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12789269-STAT3 Transcription Factor,
pubmed-meshheading:12789269-Signal Transduction,
pubmed-meshheading:12789269-Trans-Activators,
pubmed-meshheading:12789269-Transforming Growth Factor alpha,
pubmed-meshheading:12789269-Tumor Cells, Cultured,
pubmed-meshheading:12789269-Up-Regulation,
pubmed-meshheading:12789269-rac1 GTP-Binding Protein
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pubmed:year |
2003
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pubmed:articleTitle |
Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2.
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pubmed:affiliation |
Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. steinman@pitt.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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