Source:http://linkedlifedata.com/resource/pubmed/id/12788979
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2003-8-21
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| pubmed:abstractText |
This study aimed to determine whether maternal protein restriction alters hepatic glycogen metabolism. Mated female rats were fed diets containing 20% protein throughout pregnancy and lactation (CONT), 8% protein throughout pregnancy and lactation (LP), or 8% protein during the last week of pregnancy only and lactation (LLP). Weights and lengths were reduced in the LLP and LP offspring compared with the CONT offspring. The LLP and LP offspring demonstrated reduced insulin concentrations at both 10 and 26 d and also failed to show the increase in insulin seen with time in the CONT offspring. Serum glucose and leptin levels increased with time but were not different among the groups; however, in relation to adiposity leptin levels were greater in the LLP and LP offspring at 26 d. The LLP and LP offspring had increased hepatic glycogen at day 10 (CONT, 75.1 +/- 9.8; LLP, 103.4 +/- 11.0; LP, 116.0 +/- 18.4 glucose residues/g tissue) and d 26 (CONT, 183.1 +/- 38.9; LLP, 395.3 +/- 16.8; LP, 396.6 +/- 15.1 glucose residues/g tissue). Glycogen synthase expression was increased in the LLP and LP offspring at 10 d but not 26 d; glucose transporter 2 and glycogen phosphorylase expressions were not different at either time. At 26 d glycogen synthase activity was not different; however, glycogen phosphorylase a activity was reduced. The enhanced capacity to store glycogen despite reductions in insulin secretion suggests increased insulin sensitivity possibly acting with an alternative non-insulin-dependent glycogen storage mechanism.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Phosphorylase,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Liver Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0031-3998
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
413-8
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12788979-Adipose Tissue,
pubmed-meshheading:12788979-Animals,
pubmed-meshheading:12788979-Animals, Newborn,
pubmed-meshheading:12788979-Animals, Suckling,
pubmed-meshheading:12788979-Blood Glucose,
pubmed-meshheading:12788979-Body Weight,
pubmed-meshheading:12788979-Diet, Protein-Restricted,
pubmed-meshheading:12788979-Female,
pubmed-meshheading:12788979-Glucose Transporter Type 2,
pubmed-meshheading:12788979-Glycogen Phosphorylase,
pubmed-meshheading:12788979-Glycogen Synthase,
pubmed-meshheading:12788979-Insulin,
pubmed-meshheading:12788979-Lactation,
pubmed-meshheading:12788979-Leptin,
pubmed-meshheading:12788979-Liver,
pubmed-meshheading:12788979-Liver Glycogen,
pubmed-meshheading:12788979-Male,
pubmed-meshheading:12788979-Monosaccharide Transport Proteins,
pubmed-meshheading:12788979-Pregnancy,
pubmed-meshheading:12788979-Rats,
pubmed-meshheading:12788979-Rats, Wistar
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| pubmed:year |
2003
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| pubmed:articleTitle |
Maternal protein restriction increases hepatic glycogen storage in young rats.
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| pubmed:affiliation |
Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Sydney NSW 2006, Australia. agos7353@mail.usyd.edu.au
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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