Recent technological developments have facilitated explorations of the sustained signalling pathways important for lymphocyte activation. One key response necessary for lymphocyte activation is the prolonged activation of the lipid kinase phosphatidylinositol-3 kinase (PI3K). It has also been shown that there is sustained activation of diverse serine/threonine kinases in activated lymphocytes.
Division of Cell Biology and Immunology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK. doreen.cantrell@cancer.org.uk
