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rdf:type |
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lifeskim:mentions |
umls-concept:C0014597,
umls-concept:C0017262,
umls-concept:C0033684,
umls-concept:C0185117,
umls-concept:C0205307,
umls-concept:C0221910,
umls-concept:C0242379,
umls-concept:C0282637,
umls-concept:C0440744,
umls-concept:C0442821,
umls-concept:C0972212,
umls-concept:C1335813,
umls-concept:C1441616,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-5
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pubmed:abstractText |
In order to confirm 14-3-3 sigma (sigma) protein distribution in human tissues, immunohistochemistry was performed using various paraffin-embedded human tissues. In normal human tissues, the strongest immunoreactivity for 14-3-3sigma protein was observed in squamous epithelia at various sites, followed by basal cells of the trachea, bronchus and basal or myoepithelial cells of various glands. Moderate to weak 14-3-3sigma immunoreactivity was seen in the epithelial cells of the alimentary tract, gall bladder, urinary tract and endometrium. In the lung, 14-3-3sigma immunoreactivity was also observed in hyperplastic type II alveolar cells and metaplastic squamous cells. Immunohistochemical study using non-small-cell lung cancers revealed that 14-3-3sigma immunoreactivity was stronger in squamous cell carcinomas than in adenocarcinomas. The present study revealed that 14-3-3sigma expression was exclusively present in various epithelial cells and had a tendency to be stronger in cells destined for squamous epithelium or differentiating toward squamous cells in human normal and neoplastic cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1320-5463
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pubmed:author |
pubmed-author:HamanakaKozueK,
pubmed-author:IdeMunenoriM,
pubmed-author:MaedaMasahiroM,
pubmed-author:MasudaNorihikoN,
pubmed-author:MotegiAtsushiA,
pubmed-author:NakajimaTakashiT,
pubmed-author:OyamaTetsunariT,
pubmed-author:SanoTakaakiT,
pubmed-author:SegawaAtsukiA,
pubmed-author:ShimookaHanakoH,
pubmed-author:TsukagoshiHiroeH,
pubmed-author:WeixaPengP,
pubmed-author:ZhangJianJ
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12787309-14-3-3 Proteins,
pubmed-meshheading:12787309-Adenocarcinoma,
pubmed-meshheading:12787309-Blotting, Western,
pubmed-meshheading:12787309-Carcinoma, Squamous Cell,
pubmed-meshheading:12787309-Cell Count,
pubmed-meshheading:12787309-Cell Lineage,
pubmed-meshheading:12787309-Exonucleases,
pubmed-meshheading:12787309-Female,
pubmed-meshheading:12787309-Humans,
pubmed-meshheading:12787309-Immunoenzyme Techniques,
pubmed-meshheading:12787309-Lung Neoplasms,
pubmed-meshheading:12787309-Male,
pubmed-meshheading:12787309-Neoplasm Proteins,
pubmed-meshheading:12787309-Tissue Distribution,
pubmed-meshheading:12787309-Tumor Markers, Biological
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pubmed:year |
2003
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pubmed:articleTitle |
Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage.
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pubmed:affiliation |
Second Department of Pathology and The First Department of Surgery, Gunma University School of Medicine, and Immuno-Biological Laboratories Co Ltd, Gunma, Japan. nakajima@med.gunma-u.ac.jp
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pubmed:publicationType |
Journal Article
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