|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2003-6-4
|
|
pubmed:abstractText |
Germline alterations in cyclin-dependent kinase inhibitor 2A (CDKN2A) are important genetic factors in familial predisposition to melanoma. Activating mutations of the NRAS proto-oncogene are among the most common somatic genetic alterations in cutaneous malignant melanomas. We investigated the occurrence of NRAS mutations in melanomas and dysplastic nevi in individuals with germline CDKN2A mutations.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1460-2105
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
4
|
|
pubmed:volume |
95
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
790-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12783933-Codon,
pubmed-meshheading:12783933-DNA, Neoplasm,
pubmed-meshheading:12783933-Female,
pubmed-meshheading:12783933-Genes, p16,
pubmed-meshheading:12783933-Genes, ras,
pubmed-meshheading:12783933-Germ-Line Mutation,
pubmed-meshheading:12783933-Humans,
pubmed-meshheading:12783933-Incidence,
pubmed-meshheading:12783933-Male,
pubmed-meshheading:12783933-Melanoma,
pubmed-meshheading:12783933-Mutation,
pubmed-meshheading:12783933-Polymerase Chain Reaction,
pubmed-meshheading:12783933-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:12783933-Sequence Analysis, DNA,
pubmed-meshheading:12783933-Skin Neoplasms,
pubmed-meshheading:12783933-Sweden,
pubmed-meshheading:12783933-Ultraviolet Rays
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations.
|
|
pubmed:affiliation |
Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
