12783108

Source:http://linkedlifedata.com/resource/pubmed/id/12783108

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0042373, umls-concept:C0333275, umls-concept:C0521026
pubmed:issue	6
pubmed:dateCreated	2003-6-3
pubmed:abstractText	The syndrome of "viral hemorrhagic fever" in man caused by certain viruses, such as Ebola, Lassa, Dengue, and Crimean-Congo hemorrhagic fever viruses, is often associated with a shock syndrome of undetermined pathogenesis. However, the vascular system, particularly the vascular endothelium, seems to be directly and indirectly targeted by all these viruses. Here we briefly summarize the current knowledge on Marburg and Ebola virus infections, the prototype viral hemorrhagic fever agents, and formulate a working hypothesis for the pathogenesis of viral hemorrhagic fever. Infections with filoviruses show lethality up to 89% and in severe cases lead to a shock syndrome associated with hypotension, coagulation disorders and an imbalance of fluid distribution between the intravascular and extravascular tissue space. The primary target cells for filoviruses are mononuclear phagocytotic cells which are activated upon infection and release certain cytokines and chemokines. These mediators indirectly target the endothelium and are thought to play a key role in the pathogenesis of filoviral hemorrhagic fever. In addition, direct infection and subsequent destruction of endothelial cells might contribute to the pathogenesis. Filoviruses, particularly Ebola virus, encode nonstructural glycoproteins which are released from infected host cells. Their function as potential determinants in pathogenicity remains to be investigated.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7608063
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0340-6245
pubmed:author	pubmed-author:FeldmannHeinzH, pubmed-author:SchnittlerHans-JHJ
pubmed:issnType	Print
pubmed:volume	89
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	967-72
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12783108-Endothelium, Vascular, pubmed-meshheading:12783108-Hemorrhagic Fevers, Viral, pubmed-meshheading:12783108-Humans, pubmed-meshheading:12783108-Vascular Diseases
pubmed:year	2003
pubmed:articleTitle	Viral hemorrhagic fever--a vascular disease?
pubmed:affiliation	Institute of Physiology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany. hans.schnittler@mailbox.tu-dresden.de
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't