12782879

Source:http://linkedlifedata.com/resource/pubmed/id/12782879

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0684224, umls-concept:C0868928, umls-concept:C1334704
pubmed:issue	411
pubmed:dateCreated	2003-6-3
pubmed:abstractText	Five patients with primary osteosarcoma who were treated effectively with chemotherapy and resective surgery and in whom a metachronous tumor subsequently developed in another site but who never had evidence of pulmonary metastases are described. The original bone scans of the five patients showed only the primary site as being involved. After diagnosis and treatment of the initial tumor, at intervals ranging from 12 to 78 months (average, 39 months) another osteosarcoma developed in the patients at a distant bony site. After diagnosis and treatment of the second osteosarcoma, followup of these patients for a mean of 77 months (range, 24-96 months) after the appearance of the metachronous tumor and for a mean of 118 months (range, 99-150 months) after the diagnosis of the primary lesion showed that none had pulmonary metastases develop. No recurrences of the local tumors have occurred and four of the patients currently are alive and free of disease. One of the patients had a fatal acute myelogenous leukemia develop 144 months after the discovery of the primary osteosarcoma and 86 months after the appearance of the metachronous disease. At the time of her death, however she had no evidence of osteosarcoma in any site.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0075674
pubmed:citationSubset	AIM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0009-921X
pubmed:author	pubmed-author:GebhardtMark CMC, pubmed-author:HornicekFrancis JFJ, pubmed-author:MankinHenry JHJ, pubmed-author:RodriguezEdward KEK
pubmed:issnType	Print
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	227-35
pubmed:dateRevised	2005-3-3
pubmed:meshHeading	pubmed-meshheading:12782879-Adolescent, pubmed-meshheading:12782879-Adult, pubmed-meshheading:12782879-Female, pubmed-meshheading:12782879-Humans, pubmed-meshheading:12782879-Male, pubmed-meshheading:12782879-Neoplasms, Second Primary, pubmed-meshheading:12782879-Osteosarcoma
pubmed:year	2003
pubmed:articleTitle	Metachronous osteosarcoma: a report of five cases.
pubmed:affiliation	Orthopaedic Oncology Service, Massachusetts General Hospital and Children's Hospital, Harvard Medical School, Boston, MA 02114, USA.
pubmed:publicationType	Journal Article, Case Reports