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rdf:type |
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lifeskim:mentions |
umls-concept:C0007137,
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0034802,
umls-concept:C0185117,
umls-concept:C0460004,
umls-concept:C0547047,
umls-concept:C1422009,
umls-concept:C1514762,
umls-concept:C1518174,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-3
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pubmed:abstractText |
Both the epidermal growth factor receptor (EGFR) and the p53 homologue p63 are overexpressed in a significant number of cases of head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor and p63 both possess oncogenic properties, including the potential to increase cell proliferation and antagonize apoptosis. ZD1839 ("Iressa") is an adenosine triphosphate-competitive inhibitor specific to the EGFR tyrosine kinase currently under evaluation as a chemotherapeutic agent in HNSCC. The objective was to investigate whether p63 expression is decreased after treatment of HNSCC cells with ZD1839. Downregulation of p63 by ZD1839 would identify a potential molecular relationship between EGFR signaling and p63 and could provide insight into the mechanism of action of ZD1839.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CKAP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TP63 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/gefitinib
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0023-852X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
936-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12782800-Antineoplastic Agents,
pubmed-meshheading:12782800-Apoptosis,
pubmed-meshheading:12782800-Blotting, Northern,
pubmed-meshheading:12782800-Blotting, Western,
pubmed-meshheading:12782800-Carcinoma, Squamous Cell,
pubmed-meshheading:12782800-Cell Division,
pubmed-meshheading:12782800-DNA-Binding Proteins,
pubmed-meshheading:12782800-Dose-Response Relationship, Drug,
pubmed-meshheading:12782800-Down-Regulation,
pubmed-meshheading:12782800-Flow Cytometry,
pubmed-meshheading:12782800-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12782800-Genes, Tumor Suppressor,
pubmed-meshheading:12782800-Humans,
pubmed-meshheading:12782800-Membrane Proteins,
pubmed-meshheading:12782800-Mouth Neoplasms,
pubmed-meshheading:12782800-Phosphoproteins,
pubmed-meshheading:12782800-Protein-Tyrosine Kinases,
pubmed-meshheading:12782800-Quinazolines,
pubmed-meshheading:12782800-RNA, Messenger,
pubmed-meshheading:12782800-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12782800-Signal Transduction,
pubmed-meshheading:12782800-Trans-Activators,
pubmed-meshheading:12782800-Transcription Factors,
pubmed-meshheading:12782800-Tumor Cells, Cultured,
pubmed-meshheading:12782800-Tumor Suppressor Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibition of epidermal growth factor receptor signaling decreases p63 expression in head and neck squamous carcinoma cells.
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pubmed:affiliation |
Vanderbilt Bill Wilkerson Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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