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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2003-6-3
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pubmed:abstractText |
MafBx and Murf are two new rat E3 ubiquitin ligases induced in muscle atrophy. Our goal was to investigate whether lipopolysaccharide (LPS) injection, a model of muscle catabolism, is associated with increased expression of MafBx and Murf. LPS (750 microg/100 g body weight) induces MafBx and Murf mRNA (respectively, 23-fold and 33-fold after 12 h; P<0.001). A transient induction of tumor necrosis factor-alpha mRNA (21-fold; P<0.001 at 3 h) and a decrease of insulin like growth factor-I mRNA (50%; P<0.001 at 6 h), two potential regulators of the ubiquitin-proteasome system were also demonstrated. In summary, MafBx and Murf mRNA are up-regulated in response to LPS and might play a role in the muscle proteolysis observed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/FBXO32 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fbxo32 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Rnf28 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/SKP Cullin F-Box Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/TRIM63 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
544
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
214-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12782319-Animals,
pubmed-meshheading:12782319-Body Weight,
pubmed-meshheading:12782319-Ligases,
pubmed-meshheading:12782319-Lipopolysaccharides,
pubmed-meshheading:12782319-Muscle, Skeletal,
pubmed-meshheading:12782319-Muscle Proteins,
pubmed-meshheading:12782319-Muscles,
pubmed-meshheading:12782319-RNA,
pubmed-meshheading:12782319-RNA, Messenger,
pubmed-meshheading:12782319-Rats,
pubmed-meshheading:12782319-Rats, Wistar,
pubmed-meshheading:12782319-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12782319-SKP Cullin F-Box Protein Ligases,
pubmed-meshheading:12782319-Time Factors,
pubmed-meshheading:12782319-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12782319-Ubiquitin-Protein Ligases,
pubmed-meshheading:12782319-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection.
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pubmed:affiliation |
Unité de Diabétologie et Nutrition, Université catholique de Louvain, B-1200 Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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