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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-6-3
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pubmed:abstractText |
Transcription factors of the T-domain family regulate many developmental processes. We have isolated from the sea urchin a new member of the Tbx2 subfamily: coquillette. Coquillette has a late zygotic expression whose localization is dynamic: at the blastula stage it is restricted to the aboral side of most of the presumptive ectoderm and endoderm territories and from gastrulation on, to the aboral-most primary mesenchyme cells. Perturbation of coquillette function delays gastrulation and strongly disorganizes the skeleton of the larva. Coquillette is sensitive to alteration of the oral-aboral (OA) axis and we identify goosecoid, which controls oral and aboral fates in the ectoderm, as a probable upstream regulator. Coquillette appears to be an integral part of the patterning system along the OA axis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Goosecoid Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Nickel,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
561-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12782273-Amino Acid Sequence,
pubmed-meshheading:12782273-Animals,
pubmed-meshheading:12782273-Base Sequence,
pubmed-meshheading:12782273-Blotting, Northern,
pubmed-meshheading:12782273-Body Patterning,
pubmed-meshheading:12782273-Bone Development,
pubmed-meshheading:12782273-Cloning, Molecular,
pubmed-meshheading:12782273-DNA, Complementary,
pubmed-meshheading:12782273-Ectoderm,
pubmed-meshheading:12782273-Embryo, Nonmammalian,
pubmed-meshheading:12782273-Gene Expression Regulation, Developmental,
pubmed-meshheading:12782273-Goosecoid Protein,
pubmed-meshheading:12782273-Homeodomain Proteins,
pubmed-meshheading:12782273-Lithium,
pubmed-meshheading:12782273-Lithium Chloride,
pubmed-meshheading:12782273-Molecular Sequence Data,
pubmed-meshheading:12782273-Nickel,
pubmed-meshheading:12782273-Oligonucleotides, Antisense,
pubmed-meshheading:12782273-Phenotype,
pubmed-meshheading:12782273-Phylogeny,
pubmed-meshheading:12782273-Plasmids,
pubmed-meshheading:12782273-RNA, Messenger,
pubmed-meshheading:12782273-Recombinant Proteins,
pubmed-meshheading:12782273-Repressor Proteins,
pubmed-meshheading:12782273-Sea Urchins,
pubmed-meshheading:12782273-T-Box Domain Proteins,
pubmed-meshheading:12782273-Time Factors,
pubmed-meshheading:12782273-Transcription, Genetic,
pubmed-meshheading:12782273-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Coquillette, a sea urchin T-box gene of the Tbx2 subfamily, is expressed asymmetrically along the oral-aboral axis of the embryo and is involved in skeletogenesis.
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pubmed:affiliation |
Unité de Biologie du Développement, UMR 7009, CNRS, Université Pierre et Marie Curie, Observatoire Océanologique, 06230, Villefranche-sur-Mer, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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