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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-6-3
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pubmed:abstractText |
To gain further insight into the possible role of interleukin (IL)-18 in HIV-1 infection we examined serum levels of IL-18 in various clinical and immunological stages of HIV-1 infection during cross-sectional (n = 41) and longitudinal testing (n = 20) and during HAART (n = 21, 24 months follow-up). Our main findings were that HIV-1-infected patients had significantly raised IL-18 levels comparing healthy controls, particularly in those with advanced disease, that while HAART induced a marked decline in IL-18, virological treatment failure was associated with persistently raised IL-18 levels during such therapy and that our in vitro experiments showed an IL-18-mediated up-regulation of the HIV-1 coreceptor CXCR4 and the pro-apoptotic mediator TRAIL in PBMC from HIV-1-infected patients receiving HAART. HIV-1 infection appears to be characterized by persistently raised IL-18 levels and during HAART, such a pattern was associated with virological treatment failure, possibly contributing to immunodeficiency and HIV-1 replication in these patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-10705298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-10974226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-10976535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-11049971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-11110048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-11244043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-11312119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-11494162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-11675501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-12062373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-12438570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-7906293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-9334376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-9646183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12780693-9770523
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
462-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12780693-Adult,
pubmed-meshheading:12780693-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:12780693-Chemokines,
pubmed-meshheading:12780693-Cross-Sectional Studies,
pubmed-meshheading:12780693-Disease Progression,
pubmed-meshheading:12780693-Drug Resistance, Viral,
pubmed-meshheading:12780693-Female,
pubmed-meshheading:12780693-Gene Expression Regulation,
pubmed-meshheading:12780693-HIV Infections,
pubmed-meshheading:12780693-HIV-1,
pubmed-meshheading:12780693-Humans,
pubmed-meshheading:12780693-Immune Tolerance,
pubmed-meshheading:12780693-Interleukin-18,
pubmed-meshheading:12780693-Longitudinal Studies,
pubmed-meshheading:12780693-Male,
pubmed-meshheading:12780693-Middle Aged,
pubmed-meshheading:12780693-RNA, Messenger,
pubmed-meshheading:12780693-Receptors, Chemokine,
pubmed-meshheading:12780693-Treatment Failure
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pubmed:year |
2003
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pubmed:articleTitle |
Raised serum levels of interleukin-18 is associated with disease progression and may contribute to virological treatment failure in HIV-1-infected patients.
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pubmed:affiliation |
Section of Clinical Immunology and Infectious Diseases, Rikshospitalet University Hospital, Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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