Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-5-29
pubmed:abstractText
Pavlovian conditioning in Hermissenda consists of pairing light, the conditioned stimulus (CS) with activation of statocyst hair cells, the unconditioned stimulus (US). Conditioning produces CS-elicited foot shortening and inhibition of light-elicited locomotion, the two conditioned responses (CRs). Conditioning correlates have been identified in the primary sensory neurons (photoreceptors) of the CS pathway, interneurons that receive monosynaptic input from identified photoreceptors, and putative pedal motor neurons. While cellular mechanisms of acquisition produced by the synaptic interaction between the CS and US pathways are well-documented, little is known about the mechanisms responsible for the generation or expression of the CR. Here we show that in conditioned animals light reduced tonic firing of ciliary activating pedal neurons (VP1) below their pre-CS baseline levels. In contrast, pseudorandom controls expressed a significant increase in CS-elicited tonic firing of VP1 as compared to pre-CS baseline activity. Identified interneurons in the visual pathway that have established polysynaptic connections with VP1 were examined in conditioned animals and pseudorandom controls. Depolarization of identified type Ie interneurons with extrinsic current elicited a significant increase in IPSPs recorded in VP1 pedal neurons of conditioned animals as compared with pseudorandom controls. Conditioning also enhanced intrinsic excitability of type Ie interneurons of conditioned animals as compared to pseudorandom controls. Light evoked a modest increase in IPSP frequency in VP1 of conditioned preparations and a significant decrease in IPSP frequency in VP1 of pseudorandom controls. Our results show that a combination of synaptic facilitation and intrinsic enhanced excitability in identified components of the CS pathway may explain light-elicited inhibition of locomotion in conditioned animals.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-10684903, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-10899211, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-11287468, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-11784753, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-12196605, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-1617416, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-1747756, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-2853980, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-3458232, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-3711982, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-3783224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-3973682, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-4352950, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-4645675, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-4694742, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-5028660, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-6086855, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-6290619, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-641519, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-6616178, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-6816909, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-6969298, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-7058334, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-7299440, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-7807221, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-8120622, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-8331378, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-8757265, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-9151759, http://linkedlifedata.com/resource/pubmed/commentcorrection/12773585-978236
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1072-0502
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-16
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:articleTitle
Neural correlates of Pavlovian conditioning in components of the neural network supporting ciliary locomotion in Hermissenda.
pubmed:affiliation
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA. terry.crow@uth.tmc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.