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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-5-28
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pubmed:abstractText |
We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Abeta deposition. These findings suggest that unknown factors besides Abeta deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
343
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12770691-Aged,
pubmed-meshheading:12770691-Aged, 80 and over,
pubmed-meshheading:12770691-Alzheimer Disease,
pubmed-meshheading:12770691-Brain,
pubmed-meshheading:12770691-Cell Count,
pubmed-meshheading:12770691-Cyclooxygenase 2,
pubmed-meshheading:12770691-Female,
pubmed-meshheading:12770691-Hippocampus,
pubmed-meshheading:12770691-Humans,
pubmed-meshheading:12770691-Immunohistochemistry,
pubmed-meshheading:12770691-Isoenzymes,
pubmed-meshheading:12770691-Male,
pubmed-meshheading:12770691-Membrane Proteins,
pubmed-meshheading:12770691-Middle Aged,
pubmed-meshheading:12770691-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12770691-Pyramidal Cells,
pubmed-meshheading:12770691-Temporal Lobe,
pubmed-meshheading:12770691-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans.
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pubmed:affiliation |
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. oyokota1@yahoo.co.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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