| pubmed-article:12769841 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C0059249 | lld:lifeskim |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:12769841 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:12769841 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12769841 | pubmed:dateCreated | 2003-5-28 | lld:pubmed |
| pubmed-article:12769841 | pubmed:abstractText | The diverse cytoplasmic domain sequences within the various integrin subunits are critical for integrin-mediated signaling into the cell (outside-in signaling) and for activation of ligand binding affinity (inside-out signaling). Here we introduce an approach based on phage display technology to identify molecules that specifically interact with the cytoplasmic domain of the beta 5 integrin subunit. We show that a peptide selected for binding specifically to the beta 5 cytoplasmic domain (VVISYSMPD) induces apoptosis upon internalization. The cell death process induced by VVISYSMPD is sensitive to modulation by growth factors and by protein kinase C (PKC), and it cannot be triggered in beta 5 null cells. Finally, we show that the VVISYSMPD peptide is a mimic of annexin V. Our results suggest a functional link between the alpha v beta 5 integrin, annexin V, and programmed cell death. We propose the term "endothanatos" to designate this phenomenon. | lld:pubmed |
| pubmed-article:12769841 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12769841 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12769841 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12769841 | pubmed:month | May | lld:pubmed |
| pubmed-article:12769841 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:12769841 | pubmed:author | pubmed-author:ArapWadihW | lld:pubmed |
| pubmed-article:12769841 | pubmed:author | pubmed-author:Cardó-VilaMar... | lld:pubmed |
| pubmed-article:12769841 | pubmed:author | pubmed-author:PasqualiniRen... | lld:pubmed |
| pubmed-article:12769841 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12769841 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:12769841 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12769841 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12769841 | pubmed:pagination | 1151-62 | lld:pubmed |
| pubmed-article:12769841 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:meshHeading | pubmed-meshheading:12769841... | lld:pubmed |
| pubmed-article:12769841 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12769841 | pubmed:articleTitle | Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V. | lld:pubmed |
| pubmed-article:12769841 | pubmed:affiliation | M.D. Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:12769841 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12769841 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12769841 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12769841 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3693 | entrezgene:pubmed | pubmed-article:12769841 | lld:entrezgene |
| entrez-gene:308 | entrezgene:pubmed | pubmed-article:12769841 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12769841 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12769841 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12769841 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12769841 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12769841 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12769841 | lld:pubmed |
