|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2003-5-27
|
|
pubmed:abstractText |
The aim of the present study is to investigate the relation of cyclooxygenase (COX)-2 with liver metastasis. Pieces of human colon cancer xenograft were implanted orthotopically (CI), as well as intraperitoneally, and subcutaneously. Liver metastasis developed most frequently, and the COX-2 expression of both mRNA and protein of the tumors was the most dominant in the CI group. In contrast, the expression of COX-1 or vascular endothelial cell growth factor mRNAs had no significant differences among the groups. The intensity of COX-2 mRNA was negatively correlated with the apoptotic index. In conclusion, COX-2 plays an important role in organ-specific metastasis of the colon cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0304-3835
|
|
pubmed:author |
pubmed-author:BabaMegumiM,
pubmed-author:IgarashiAkiraA,
pubmed-author:KamiyaKinjiK,
pubmed-author:KanekoTakeshiT,
pubmed-author:KonnoHiroyukiH,
pubmed-author:NakamuraSatoshiS,
pubmed-author:OhtaManabuM,
pubmed-author:SakaguchiTakanoriT,
pubmed-author:ShojiTuyoshiT,
pubmed-author:SunayamaKenichiK,
pubmed-author:TanakaTatsuoT
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
195
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
235-41
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12767532-Adenocarcinoma,
pubmed-meshheading:12767532-Animals,
pubmed-meshheading:12767532-Apoptosis,
pubmed-meshheading:12767532-Cecum,
pubmed-meshheading:12767532-Colonic Neoplasms,
pubmed-meshheading:12767532-Cyclooxygenase 1,
pubmed-meshheading:12767532-Cyclooxygenase 2,
pubmed-meshheading:12767532-Endothelial Growth Factors,
pubmed-meshheading:12767532-Enzyme Induction,
pubmed-meshheading:12767532-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12767532-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12767532-Isoenzymes,
pubmed-meshheading:12767532-Liver Neoplasms,
pubmed-meshheading:12767532-Lymphokines,
pubmed-meshheading:12767532-Male,
pubmed-meshheading:12767532-Membrane Proteins,
pubmed-meshheading:12767532-Mice,
pubmed-meshheading:12767532-Mice, Inbred BALB C,
pubmed-meshheading:12767532-Mice, Nude,
pubmed-meshheading:12767532-Neoplasm Proteins,
pubmed-meshheading:12767532-Neoplasm Transplantation,
pubmed-meshheading:12767532-Neovascularization, Pathologic,
pubmed-meshheading:12767532-Organ Specificity,
pubmed-meshheading:12767532-Peritoneal Cavity,
pubmed-meshheading:12767532-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12767532-RNA, Messenger,
pubmed-meshheading:12767532-RNA, Neoplasm,
pubmed-meshheading:12767532-Skin,
pubmed-meshheading:12767532-Specific Pathogen-Free Organisms,
pubmed-meshheading:12767532-Transplantation, Heterologous,
pubmed-meshheading:12767532-Transplantation, Heterotopic,
pubmed-meshheading:12767532-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12767532-Vascular Endothelial Growth Factors
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2.
|
|
pubmed:affiliation |
Department of Surgery II, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu-shi, Shizuoka, 431-3192, Japan. tsyoji@hama-med.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
