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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0079068,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0249197,
umls-concept:C0288472,
umls-concept:C0598934,
umls-concept:C0679622,
umls-concept:C1280500,
umls-concept:C1420626,
umls-concept:C1512474,
umls-concept:C1515655,
umls-concept:C2607887,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2003-5-27
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pubmed:abstractText |
In this study, we examined the effects of FK228 (FR901228, depsipeptide) on tumor growth and expression of p21 and c-myc genes in vivo. FK228 induced the expression of p21 mRNA and decreased c-myc mRNA in tumor xenograft sensitive to FK228. However, FK228 did not sufficiently modulate the expression of p21 mRNA and increased the expression of c-myc in tumor xenograft less sensitive to FK228. The modulation of p21 and/or c-myc genes may be critical for the marked antitumor activity of FK228 in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Depsipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/romidepsin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12767524-Acetylation,
pubmed-meshheading:12767524-Adenocarcinoma,
pubmed-meshheading:12767524-Adrenal Gland Neoplasms,
pubmed-meshheading:12767524-Animals,
pubmed-meshheading:12767524-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:12767524-Carcinoma, Renal Cell,
pubmed-meshheading:12767524-Carcinoma, Small Cell,
pubmed-meshheading:12767524-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:12767524-Cyclins,
pubmed-meshheading:12767524-Depsipeptides,
pubmed-meshheading:12767524-Enzyme Inhibitors,
pubmed-meshheading:12767524-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12767524-Genes, myc,
pubmed-meshheading:12767524-Histone Deacetylase Inhibitors,
pubmed-meshheading:12767524-Humans,
pubmed-meshheading:12767524-Kidney Neoplasms,
pubmed-meshheading:12767524-Lung Neoplasms,
pubmed-meshheading:12767524-Male,
pubmed-meshheading:12767524-Mice,
pubmed-meshheading:12767524-Mice, Inbred BALB C,
pubmed-meshheading:12767524-Mice, Nude,
pubmed-meshheading:12767524-Neoplasm Proteins,
pubmed-meshheading:12767524-Peptides, Cyclic,
pubmed-meshheading:12767524-Pheochromocytoma,
pubmed-meshheading:12767524-Prostatic Neoplasms,
pubmed-meshheading:12767524-Protein Processing, Post-Translational,
pubmed-meshheading:12767524-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:12767524-RNA, Messenger,
pubmed-meshheading:12767524-RNA, Neoplasm,
pubmed-meshheading:12767524-Tumor Cells, Cultured,
pubmed-meshheading:12767524-Xenograft Model Antitumor Assays
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pubmed:year |
2003
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pubmed:articleTitle |
Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo.
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pubmed:affiliation |
Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka, 532-8514, Japan. yuka_sasakawa@po.fujisawa.co.jp
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pubmed:publicationType |
Journal Article
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