Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-5-27
pubmed:abstractText
We demonstrate here unexpectedly long-lasting effect of transcutaneous electrical nerve stimulation (TENS) to alleviate thermal hyperalgesia in rats with peripheral neuropathy produced by constriction of sciatic nerve. For TENS groups, electrical stimulation for 16.7 min (1 Hz, paired current, 12 mA, 5-ms interval, 0.2-ms duration, 999 pairs), once a day, was delivered for 5 consecutive days, under halothane anesthesia (Hal-TENS group) or pentobarbital anesthesia (Pent-TENS group). For non-TENS groups, only the anesthesia was delivered (Hal-no TENS group, Pent-no TENS group). For the control group, neither anesthetics nor TENS was delivered. To evaluate hyperalgesia, paw withdrawal latency (PWL) to radiant heat was measured before nerve constriction and five times after the constriction; just before TENS and at 1, 3, 7, and 14 days after the completion of TENS. Compared to the non-TENS groups, rats in the TENS groups showed significantly reduced thermal hyperalgesia at least for 3 days (Pent-TENS group) or for 7 days (Hal-TENS group) after TENS. These results indicate a possible long-lasting therapeutic effect of TENS applied under general anesthesia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
211
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12767496-Anesthetics, Inhalation, pubmed-meshheading:12767496-Animals, pubmed-meshheading:12767496-Constriction, pubmed-meshheading:12767496-Disease Models, Animal, pubmed-meshheading:12767496-Halothane, pubmed-meshheading:12767496-Hot Temperature, pubmed-meshheading:12767496-Hyperalgesia, pubmed-meshheading:12767496-Hypnotics and Sedatives, pubmed-meshheading:12767496-Male, pubmed-meshheading:12767496-Pain Measurement, pubmed-meshheading:12767496-Pentobarbital, pubmed-meshheading:12767496-Peripheral Nervous System Diseases, pubmed-meshheading:12767496-Rats, pubmed-meshheading:12767496-Rats, Sprague-Dawley, pubmed-meshheading:12767496-Reaction Time, pubmed-meshheading:12767496-Sciatic Nerve, pubmed-meshheading:12767496-Time Factors, pubmed-meshheading:12767496-Transcutaneous Electric Nerve Stimulation
pubmed:year
2003
pubmed:articleTitle
Long-lasting effect of transcutaneous electrical nerve stimulation on the thermal hyperalgesia in the rat model of peripheral neuropathy.
pubmed:affiliation
Department of Acute Critical Medicine (Anesthesiology), Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan. inoue@anes.med.osaka-u.ac.jp
pubmed:publicationType
Journal Article, Comparative Study