| pubmed-article:12766879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C0018133 | lld:lifeskim |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12766879 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12766879 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12766879 | pubmed:dateCreated | 2003-5-26 | lld:pubmed |
| pubmed-article:12766879 | pubmed:abstractText | Tumor necrosis factor-alpha (TNF-alpha) antagonist therapy has proven effective in inflammatory conditions such as rheumatoid arthritis and Crohn's disease. There is substantial evidence that TNF-alpha also plays a role in the development of graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation, which along with leukemia relapse remains one of the 2 major impediments to success of the approach. Using a recently developed potent rat/mouse chimeric monoclonal antibody directed against murine TNF-alpha (CNTO2213), the authors investigated the effect of TNF-alpha blockade on GVHD mediated by either CD4(+) or CD8(+) donor T cells. The results indicated that the treatment had only a moderate effect on both a CD8(+) T cell-mediated major histocompatibility complex-matched GVHD model involving multiple minor histocompatibility antigens and a p-->F(1) acute GVHD model directed against a haplo-mismatched major histocompatibility complex barrier involving both CD4(+) and CD8(+) T cells. In contrast, treatment with the anti-TNF-alpha antibody had a highly significant effect (100% survival rate) on the CD4(+) T cell-mediated component of this latter model. Importantly, anti-TNF-alpha antibody did not block the development of a graft-versus-leukemia effect against a murine myeloid leukemia challenge in either a syngeneic or allogeneic p-->F(1) setting. This suggests that the inhibition of TNF-alpha during allogeneic hematopoietic cell transplantation may be able to diminish the inflammatory GVHD reaction without hindering effective graft-versus-leukemia responses. | lld:pubmed |
| pubmed-article:12766879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12766879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766879 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12766879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12766879 | pubmed:month | May | lld:pubmed |
| pubmed-article:12766879 | pubmed:issn | 1083-8791 | lld:pubmed |
| pubmed-article:12766879 | pubmed:author | pubmed-author:KorngoldRober... | lld:pubmed |
| pubmed-article:12766879 | pubmed:author | pubmed-author:MurphyGeorge... | lld:pubmed |
| pubmed-article:12766879 | pubmed:author | pubmed-author:MariniJoseph... | lld:pubmed |
| pubmed-article:12766879 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:12766879 | pubmed:author | pubmed-author:Giles-KomarJi... | lld:pubmed |
| pubmed-article:12766879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12766879 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12766879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12766879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12766879 | pubmed:pagination | 292-303 | lld:pubmed |
| pubmed-article:12766879 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12766879 | pubmed:meshHeading | pubmed-meshheading:12766879... | lld:pubmed |
| pubmed-article:12766879 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12766879 | pubmed:articleTitle | Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses. | lld:pubmed |
| pubmed-article:12766879 | pubmed:affiliation | Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA. R.Korngold@mail.jci.tju.edu | lld:pubmed |
| pubmed-article:12766879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12766879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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