| pubmed-article:12766765 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C0376613 | lld:lifeskim |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12766765 | lifeskim:mentions | umls-concept:C1511253 | lld:lifeskim |
| pubmed-article:12766765 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12766765 | pubmed:dateCreated | 2003-6-2 | lld:pubmed |
| pubmed-article:12766765 | pubmed:abstractText | In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon (IFN)-gamma-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adhesion protein (TRAP). These responses are five- to tenfold higher than the T-cell responses induced by the DNA vaccine or recombinant MVA vaccine alone, and produce partial protection manifest as delayed parasitemia after sporozoite challenge with a different strain of Plasmodium falciparum. Such heterologous prime-boost immunization approaches may provide a basis for preventative and therapeutic vaccination in humans. | lld:pubmed |
| pubmed-article:12766765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766765 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12766765 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766765 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12766765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12766765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12766765 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12766765 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12766765 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:MoraYY | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:SmithGeoffrey... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:BrownKarenK | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:GilbertSarah... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:HannanCarolyn... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:HillAdrian... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:McConkeySamue... | lld:pubmed |
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| pubmed-article:12766765 | pubmed:author | pubmed-author:ButcherGeoffG | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:BlanchardTom... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:GothardPhilip... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:WatkinsKateK | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:EveraereSimon... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:CummingsJames... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:PathanAnsarA | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:FlanaganKatie... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:RobertsMark... | lld:pubmed |
| pubmed-article:12766765 | pubmed:author | pubmed-author:RoyMichaelM | lld:pubmed |
| pubmed-article:12766765 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12766765 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12766765 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12766765 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12766765 | pubmed:pagination | 729-35 | lld:pubmed |
| pubmed-article:12766765 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12766765 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12766765 | pubmed:articleTitle | Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. | lld:pubmed |
| pubmed-article:12766765 | pubmed:affiliation | Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK. | lld:pubmed |
| pubmed-article:12766765 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12766765 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12766765 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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