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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-2
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pubmed:abstractText |
In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon (IFN)-gamma-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adhesion protein (TRAP). These responses are five- to tenfold higher than the T-cell responses induced by the DNA vaccine or recombinant MVA vaccine alone, and produce partial protection manifest as delayed parasitemia after sporozoite challenge with a different strain of Plasmodium falciparum. Such heterologous prime-boost immunization approaches may provide a basis for preventative and therapeutic vaccination in humans.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Malaria Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/thrombospondin-related adhesive...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:ArulananthamNirmalanN,
pubmed-author:BlanchardTom JTJ,
pubmed-author:BrownKarenK,
pubmed-author:ButcherGeoffG,
pubmed-author:CummingsJamesJ,
pubmed-author:DunachieSusannaS,
pubmed-author:EveraereSimoneS,
pubmed-author:FlanaganKatieK,
pubmed-author:GilbertSarah CSC,
pubmed-author:GothardPhilipP,
pubmed-author:HannanCarolyn MCM,
pubmed-author:HeppnerD GrayDG,
pubmed-author:HillAdrian V SAV,
pubmed-author:KesterKent EKE,
pubmed-author:McConkeySamuel JSJ,
pubmed-author:MoorthyVasee SVS,
pubmed-author:MoraYY,
pubmed-author:PathanAnsarA,
pubmed-author:ReeceWilliam H HWH,
pubmed-author:RobertsMark T MMT,
pubmed-author:RoyMichaelM,
pubmed-author:SchneiderJoergJ,
pubmed-author:SindenRobert ERE,
pubmed-author:SmithGeoffrey LGL,
pubmed-author:VuolaJenni MJM,
pubmed-author:WatkinsKateK,
pubmed-author:WebsterDanielD,
pubmed-author:WilliamsJackieJ
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
729-35
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12766765-Animals,
pubmed-meshheading:12766765-Antigens, Protozoan,
pubmed-meshheading:12766765-Humans,
pubmed-meshheading:12766765-Immunization, Secondary,
pubmed-meshheading:12766765-Immunization Schedule,
pubmed-meshheading:12766765-Interferon-gamma,
pubmed-meshheading:12766765-Lymphocyte Activation,
pubmed-meshheading:12766765-Malaria, Falciparum,
pubmed-meshheading:12766765-Malaria Vaccines,
pubmed-meshheading:12766765-Peptides,
pubmed-meshheading:12766765-Plasmids,
pubmed-meshheading:12766765-Plasmodium falciparum,
pubmed-meshheading:12766765-Protozoan Proteins,
pubmed-meshheading:12766765-T-Lymphocytes,
pubmed-meshheading:12766765-Vaccines, DNA,
pubmed-meshheading:12766765-Vaccines, Synthetic,
pubmed-meshheading:12766765-Vaccinia virus
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pubmed:year |
2003
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pubmed:articleTitle |
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.
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pubmed:affiliation |
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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