Linked Life Data

12765846

Source:http://linkedlifedata.com/resource/pubmed/id/12765846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-5-26
pubmed:abstractText
Serum lipid responses to dietary modification are partly determined by genetic factors. The objective of the present study was to investigate the influence of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene on serum lipid and lipoprotein responses to n-3 fatty acid supplementation. A total of 76 men and 74 women (age 49+/-8 years, body mass index 26.5+/-3.0 kg/m(2)) participated in a controlled multi-center study. Subjects were randomly assigned to consume either fish oil supplements (3.6g n-3 fatty acids/day containing 2.4 g of EPA and DHA) or placebo capsules containing olive oil for 3 months. At baseline, the Pro12Ala polymorphism was not associated with serum total and lipoprotein lipid concentrations or lipoprotein lipase activity in the fasting state. After the 3-month study period, carriers of the Ala12 allele presented a greater decrease in serum triacylglycerol concentration in response to n-3 fatty acid supplementation than did subjects with the Pro12Pro genotype when the total dietary fat intake was below 37 E% (p=0.003) or the intake of saturated fatty acids was below 10 E% (p=0.006). Changes in serum total cholesterol, serum LDL cholesterol and HDL cholesterol concentrations were similar among the genotypes in the n-3 fatty acid supplementation group and in the placebo group. In conclusion, the Pro12Ala polymorphism of the PPAR-gamma2 gene may modify the inter-individual variability in serum triacylglycerol response to n-3 fatty acid supplementation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1096-7192
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12765846-Adult, pubmed-meshheading:12765846-Aged, pubmed-meshheading:12765846-Body Mass Index, pubmed-meshheading:12765846-Cholesterol, HDL, pubmed-meshheading:12765846-Cholesterol, LDL, pubmed-meshheading:12765846-Dietary Supplements, pubmed-meshheading:12765846-Fatty Acids, Omega-3, pubmed-meshheading:12765846-Female, pubmed-meshheading:12765846-Fish Oils, pubmed-meshheading:12765846-Genotype, pubmed-meshheading:12765846-Humans, pubmed-meshheading:12765846-Lipoprotein Lipase, pubmed-meshheading:12765846-Male, pubmed-meshheading:12765846-Middle Aged, pubmed-meshheading:12765846-Plant Oils, pubmed-meshheading:12765846-Polymorphism, Genetic, pubmed-meshheading:12765846-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:12765846-Transcription Factors, pubmed-meshheading:12765846-Triglycerides
pubmed:year
2003
pubmed:articleTitle
Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation.
pubmed:affiliation
University of Kuopio, Department of Clinical Nutrition, Finland. Virpi.Lindi@uku.fi
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study