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rdf:type |
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lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0008902,
umls-concept:C0017287,
umls-concept:C0032520,
umls-concept:C0035647,
umls-concept:C0205263,
umls-concept:C0243161,
umls-concept:C0444930,
umls-concept:C0524889,
umls-concept:C0936012,
umls-concept:C1257890,
umls-concept:C1442989,
umls-concept:C1511790,
umls-concept:C1522642,
umls-concept:C1704387,
umls-concept:C1707455
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pubmed:issue |
1
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pubmed:dateCreated |
2003-5-23
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pubmed:abstractText |
The initial response to induction therapy is currently considered one of the most important prognostic factors in acute lymphoblastic leukemias (ALL). A series of methods for the detection of submicroscopic levels of residual disease in patients with ALL mainly based on PCR and immunophenotyping has been developed, demonstrating that the presence of high levels of residual disease at the end of induction therapy is an important, independent prognostic factor. We determined the usefulness of PCR detection of minimal residual disease using consensus primers as a non-remission criterion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0098-1532
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12764736-Adolescent,
pubmed-meshheading:12764736-Bone Marrow,
pubmed-meshheading:12764736-Child,
pubmed-meshheading:12764736-Child, Preschool,
pubmed-meshheading:12764736-Clone Cells,
pubmed-meshheading:12764736-DNA, Neoplasm,
pubmed-meshheading:12764736-DNA Primers,
pubmed-meshheading:12764736-Disease-Free Survival,
pubmed-meshheading:12764736-Female,
pubmed-meshheading:12764736-Gene Rearrangement, delta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:12764736-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:12764736-Genes, T-Cell Receptor delta,
pubmed-meshheading:12764736-Genes, T-Cell Receptor gamma,
pubmed-meshheading:12764736-Humans,
pubmed-meshheading:12764736-Immunoglobulin Heavy Chains,
pubmed-meshheading:12764736-Immunophenotyping,
pubmed-meshheading:12764736-Infant,
pubmed-meshheading:12764736-Male,
pubmed-meshheading:12764736-Neoplasm, Residual,
pubmed-meshheading:12764736-Polymerase Chain Reaction,
pubmed-meshheading:12764736-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:12764736-Predictive Value of Tests,
pubmed-meshheading:12764736-Proportional Hazards Models,
pubmed-meshheading:12764736-Remission Induction,
pubmed-meshheading:12764736-Sensitivity and Specificity
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pubmed:year |
2003
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pubmed:articleTitle |
PCR detection of clonal IgH and TCR gene rearrangements at the end of induction as a non-remission criterion in children with ALL: comparison with standard morphologic analysis and risk group classification.
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pubmed:affiliation |
Department of Pediatrics, Ribeirão Preto Medicine School, São Paulo University, Ribeirão Preto, Brazil.
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pubmed:publicationType |
Journal Article,
Evaluation Studies
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