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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-5-23
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pubmed:abstractText |
Extensive WHO collaborative studies were performed to evaluate the suitability of transgenic mice susceptible to poliovirus (TgPVR mice, strain 21, bred and provided by the Central Institute for Experimental Animals, Japan) as an alternative to monkeys in the neurovirulence test (NVT) of oral poliovirus vaccine (OPV).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0042-9686
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pubmed:author |
pubmed-author:AbeShinobuS,
pubmed-author:DragunskyEugeniaE,
pubmed-author:FureszJohnJ,
pubmed-author:HeathAlanA,
pubmed-author:IvshinaAnnaA,
pubmed-author:KarganovaGalinaG,
pubmed-author:KarpinskiKazimirK,
pubmed-author:KurataTakeshiT,
pubmed-author:LevenbookInessaI,
pubmed-author:NomuraTatsujiT,
pubmed-author:PervikovYuriY,
pubmed-author:TaffsRolfR,
pubmed-author:VanloockeOlivierO,
pubmed-author:WoodDavid JDJ
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-60
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pubmed:dateRevised |
2009-5-29
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pubmed:meshHeading |
pubmed-meshheading:12764491-Animals,
pubmed-meshheading:12764491-Central Nervous System,
pubmed-meshheading:12764491-Cooperative Behavior,
pubmed-meshheading:12764491-Female,
pubmed-meshheading:12764491-Laboratories,
pubmed-meshheading:12764491-Macaca mulatta,
pubmed-meshheading:12764491-Male,
pubmed-meshheading:12764491-Mice,
pubmed-meshheading:12764491-Mice, Transgenic,
pubmed-meshheading:12764491-Poliovirus,
pubmed-meshheading:12764491-Poliovirus Vaccine, Oral,
pubmed-meshheading:12764491-Sensitivity and Specificity,
pubmed-meshheading:12764491-Virulence,
pubmed-meshheading:12764491-World Health Organization
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pubmed:year |
2003
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pubmed:articleTitle |
Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study.
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pubmed:affiliation |
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852-1448, USA. dragunsky@cber.fda.gov
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pubmed:publicationType |
Journal Article,
Comparative Study,
Validation Studies
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