Linked Life Data

12763873

Source:http://linkedlifedata.com/resource/pubmed/id/12763873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-5-23
pubmed:abstractText
Signaling transduction mediated by protein aggregates within specific microdomains has been receiving increased attention. We previously showed that Na,K-ATPase, partially inhibited by ouabain, induces intracellular calcium (Ca(2+)) oscillations which involve Ca(2+) release from the endoplasmic reticulum (ER). Plasma membrane bound Na,K-ATPase and proteins in the ER are in close proximity to each other, and signal transduction may occur via a physical interaction or a microdomain. To study these signaling pathways and intricate microenvironments, sophisticated methods are required. One way to detect molecular interactions in the nanometer scale (1-10 nm) is fluorescence resonance energy transfer (FRET). Thus, FRET provides vital insight into the action of Na,K-ATPase to trigger intracellular signaling events.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
986
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
514-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Visualization of Na,K-ATPase interacting proteins using FRET technique.
pubmed:affiliation
Department of Woman and Child Health, Karolinska Intitutet, Astrid Lindgren Children's Hospital, S-171 76, Stockholm, Sweden. per.uhlen@kbh.ki.se
pubmed:publicationType
Journal Article