Linked Life Data

12762809

Source:http://linkedlifedata.com/resource/pubmed/id/12762809

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-5-23
pubmed:abstractText
The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC(50) = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
690-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.
pubmed:affiliation
Laboratoire de Pharmacognosie, UMR 8076 CNRS (BioCIS), Faculté de Pharmacie, Université Paris XI, 92296 Châtenay-Malabry Cedex, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't