Linked Life Data

12762792

Source:http://linkedlifedata.com/resource/pubmed/id/12762792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-5-23
pubmed:abstractText
Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1alpha,6alpha-diol (2), 5-epi-eudesm-4(15)-ene-1beta,6beta-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1beta,6beta-diol (3), eudesm-4(15)-ene-1beta,6alpha-diol (5), octahydro-4-hydroxy-3alpha-methyl-7-methylene-alpha-(1-methylethyl)-1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-alpha-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC(50) values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) microg/mL (microM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-15
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
New Sesquiterpenes from Litsea verticillata.
pubmed:affiliation
Program for Collaborative Research in the Pharmaceutical Sciences (m/c877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, 60612, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.