Linked Life Data

12761628

Source:http://linkedlifedata.com/resource/pubmed/id/12761628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-5-22
pubmed:abstractText
Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0340-5354
pubmed:author
pubmed:issnType
Print
pubmed:volume
250 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
I3-10
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.
pubmed:affiliation
Department of Medical Genetics, University of Tübingen, Calwer Strasse 7, 72076 Tübingen, Germany. olaf.riess@med.uni-tuebingen.de
pubmed:publicationType
Journal Article, Review