| pubmed-article:12759886 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12759886 | lifeskim:mentions | umls-concept:C0022671 | lld:lifeskim |
| pubmed-article:12759886 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:12759886 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:12759886 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12759886 | pubmed:dateCreated | 2003-5-21 | lld:pubmed |
| pubmed-article:12759886 | pubmed:abstractText | The high prevalence of post-transplant glucose intolerance and insulin resistance (IR) is associated with older age, family history of diabetes, immunosuppressive drugs, and antihypertensive therapy. However, the potential determinants of post-transplant beta-cell dysfunction are largely unknown. The objective of the present study was to address this issue in detail. A total of 167 previously nondiabetic renal transplant recipients underwent a 75-g oral glucose tolerance test (OGTT)10 weeks after transplantation. Serum glucose and insulin were measured at 0, 1, and 2 hours. Three insulin release indices (Secr(AUC), Secr(1.phase), and Secr(2.phase)) were calculated to assess the insulin secretory response as the dependent variable. To account for variations in insulin sensitivity (IS), beta-cell function was also estimated as the disposition index (DI); the product of the IS index (ISI(TX)) and Secr(1.phase). Increasing age was strongly and independently associated with a blunted insulin secretory response even after adjustment for IS (P =.001). An 80-year-old recipient had an approximately 50% lower insulin release than a 20-year-old individual, based on the linear regression model. Cytomegalovirus (CMV) disease and treatment with furosemide were both independently associated with beta-cell dysfunction (DI; P <.001 and P =.008). Patients treated with angiotensin-converting enzyme (ACE)-inhibitors had an enhanced absolute insulin release, but the DI was similar in both treated and untreated recipients. We conclude that older age is an important determinant of beta-cell dysfunction after renal transplantation. CMV disease and treatment with furosemide may also negatively influence pancreatic insulin release in renal transplant recipients. | lld:pubmed |
| pubmed-article:12759886 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12759886 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12759886 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12759886 | pubmed:month | May | lld:pubmed |
| pubmed-article:12759886 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:12759886 | pubmed:author | pubmed-author:JenssenTrondT | lld:pubmed |
| pubmed-article:12759886 | pubmed:author | pubmed-author:EgelandThoreT | lld:pubmed |
| pubmed-article:12759886 | pubmed:author | pubmed-author:HartmannAnder... | lld:pubmed |
| pubmed-article:12759886 | pubmed:author | pubmed-author:HjelmesaethJø... | lld:pubmed |
| pubmed-article:12759886 | pubmed:author | pubmed-author:HagenMonicaM | lld:pubmed |
| pubmed-article:12759886 | pubmed:copyrightInfo | Copyright 2003 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:12759886 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12759886 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:12759886 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12759886 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12759886 | pubmed:pagination | 573-8 | lld:pubmed |
| pubmed-article:12759886 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12759886 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12759886 | pubmed:articleTitle | Determinants of insulin secretion after renal transplantation. | lld:pubmed |
| pubmed-article:12759886 | pubmed:affiliation | Department of Medicine, Section of Nephrology, Rikshospitalet, University of Oslo, Oslo, Norway. | lld:pubmed |
| pubmed-article:12759886 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12759886 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12759886 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12759886 | lld:pubmed |
