Linked Life Data

12759886

Source:http://linkedlifedata.com/resource/pubmed/id/12759886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-5-21
pubmed:abstractText
The high prevalence of post-transplant glucose intolerance and insulin resistance (IR) is associated with older age, family history of diabetes, immunosuppressive drugs, and antihypertensive therapy. However, the potential determinants of post-transplant beta-cell dysfunction are largely unknown. The objective of the present study was to address this issue in detail. A total of 167 previously nondiabetic renal transplant recipients underwent a 75-g oral glucose tolerance test (OGTT)10 weeks after transplantation. Serum glucose and insulin were measured at 0, 1, and 2 hours. Three insulin release indices (Secr(AUC), Secr(1.phase), and Secr(2.phase)) were calculated to assess the insulin secretory response as the dependent variable. To account for variations in insulin sensitivity (IS), beta-cell function was also estimated as the disposition index (DI); the product of the IS index (ISI(TX)) and Secr(1.phase). Increasing age was strongly and independently associated with a blunted insulin secretory response even after adjustment for IS (P =.001). An 80-year-old recipient had an approximately 50% lower insulin release than a 20-year-old individual, based on the linear regression model. Cytomegalovirus (CMV) disease and treatment with furosemide were both independently associated with beta-cell dysfunction (DI; P <.001 and P =.008). Patients treated with angiotensin-converting enzyme (ACE)-inhibitors had an enhanced absolute insulin release, but the DI was similar in both treated and untreated recipients. We conclude that older age is an important determinant of beta-cell dysfunction after renal transplantation. CMV disease and treatment with furosemide may also negatively influence pancreatic insulin release in renal transplant recipients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0026-0495
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Elsevier Inc. All rights reserved.
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
573-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12759886-Adolescent, pubmed-meshheading:12759886-Adrenergic beta-Antagonists, pubmed-meshheading:12759886-Adult, pubmed-meshheading:12759886-Aged, pubmed-meshheading:12759886-Aged, 80 and over, pubmed-meshheading:12759886-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:12759886-Antihypertensive Agents, pubmed-meshheading:12759886-Area Under Curve, pubmed-meshheading:12759886-Cyclosporine, pubmed-meshheading:12759886-Cytomegalovirus Infections, pubmed-meshheading:12759886-Diabetes Mellitus, pubmed-meshheading:12759886-Diuretics, pubmed-meshheading:12759886-Female, pubmed-meshheading:12759886-Furosemide, pubmed-meshheading:12759886-Glucose Tolerance Test, pubmed-meshheading:12759886-HLA-B27 Antigen, pubmed-meshheading:12759886-Humans, pubmed-meshheading:12759886-Immunosuppressive Agents, pubmed-meshheading:12759886-Insulin, pubmed-meshheading:12759886-Kidney Transplantation, pubmed-meshheading:12759886-Male, pubmed-meshheading:12759886-Middle Aged, pubmed-meshheading:12759886-Postoperative Complications, pubmed-meshheading:12759886-Regression Analysis, pubmed-meshheading:12759886-Risk Factors
pubmed:year
2003
pubmed:articleTitle
Determinants of insulin secretion after renal transplantation.
pubmed:affiliation
Department of Medicine, Section of Nephrology, Rikshospitalet, University of Oslo, Oslo, Norway.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't