Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-5-21
pubmed:databankReference
pubmed:abstractText
IFN-kappa belongs to a recently identified subclass of type I IFNs. In this study, we report the cloning and preliminary characterization of the murine homologue of IFN-kappa. The gene encodes a 200-aa protein which is 38.5% homologous to human IFN-kappa. Murine IFN-kappa contains four cysteines in analogous positions to those observed in the IFN-alpha and an additional fifth unique cysteine, C174. The murine gene is located on chromosome 4, where other type I murine IFN genes, IFN-alpha and IFN-beta, are clustered. This region is syntenic with human chromosome 9 where the gene encoding IFN-kappa and the type I IFN gene cluster are found. Mouse IFN-kappa is expressed at low levels in peritoneal macrophages and its expression is up-regulated by dsRNA and IFN-gamma. Similar to previously reported transgenic mice carrying type I and type II IFNs, transgenic mice overexpressing murine IFN-kappa in the beta cells of the pancreas develop overt diabetes with hyperglycemia. Histological characterization of pancreatic islets from these transgenic mice showed inflammatory infiltrates with corresponding destruction of beta cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5748-55
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12759458-Amino Acid Sequence, pubmed-meshheading:12759458-Animals, pubmed-meshheading:12759458-Base Sequence, pubmed-meshheading:12759458-Cloning, Molecular, pubmed-meshheading:12759458-Diabetes Mellitus, Type 1, pubmed-meshheading:12759458-Humans, pubmed-meshheading:12759458-Interferon Type I, pubmed-meshheading:12759458-Interferon-gamma, pubmed-meshheading:12759458-Islets of Langerhans, pubmed-meshheading:12759458-Macrophages, Peritoneal, pubmed-meshheading:12759458-Mice, pubmed-meshheading:12759458-Mice, Inbred C57BL, pubmed-meshheading:12759458-Mice, Inbred DBA, pubmed-meshheading:12759458-Mice, Transgenic, pubmed-meshheading:12759458-Molecular Sequence Data, pubmed-meshheading:12759458-RNA, Double-Stranded, pubmed-meshheading:12759458-Sequence Alignment, pubmed-meshheading:12759458-Sequence Homology, Amino Acid, pubmed-meshheading:12759458-Sequence Homology, Nucleic Acid
pubmed:year
2003
pubmed:articleTitle
Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice.
pubmed:affiliation
Department of Immunology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't