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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-8-2
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pubmed:abstractText |
We investigated the membrane of En(a-) human erythrocytes as part of a study of the structure and biochemical function of the surface glycoproteins of the mammalian cell. 2. En(a-) erythrocytes were selected because they have more extensive changes at the cell surface than any other known erythrocyte variant. 3. Our results show that in En(a-) erythrocytes: (a) the major membrane sialoglycoprotein is lacking; (b) the other major membrane-penetrating glycoprotein (band 3) has an altered electrophoretic mobility. 4. The apparent clinical normality of En(a-) cells suggests that the change in band 3 may compensate for the loss of the membrane sialoglycoproteins. It is clear that a viable erythrocyte can exist despite the absence of one of its major surface components.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-1167151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-1172890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-1275889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-13672998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-14332936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4423057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4436325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4462620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4530270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4600883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4682513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4722837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4724478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4770788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4806351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4838037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4841336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4982653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-4993956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-5359398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1275890-803103
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1275890-Binding Sites, Antibody,
pubmed-meshheading:1275890-Blood Group Antigens,
pubmed-meshheading:1275890-Cell Membrane,
pubmed-meshheading:1275890-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:1275890-Erythrocytes, Abnormal,
pubmed-meshheading:1275890-Glycoproteins,
pubmed-meshheading:1275890-Iodine Radioisotopes,
pubmed-meshheading:1275890-Lectins,
pubmed-meshheading:1275890-MNSs Blood-Group System,
pubmed-meshheading:1275890-Molecular Weight,
pubmed-meshheading:1275890-Neuraminidase
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pubmed:year |
1976
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pubmed:articleTitle |
The membrane change in En(a-) human erythrocytes. Absence of the major erythrocyte sialoglycoprotein.
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pubmed:publicationType |
Journal Article
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