Linked Life Data

12758202

Source:http://linkedlifedata.com/resource/pubmed/id/12758202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2003-5-21
pubmed:abstractText
The ability to study the early events in the pathogenesis of pulmonary tuberculosis in guinea pigs following very low dose (3-5 cfu) infection by the respiratory route has revealed that early (10-14 days) extrapulmonary dissemination results in reseeding of previously uninfected lobes of the lung by the hematogenous route. Thus, in every guinea pig, the lung is challenged twice, once by the airway and 2-3 weeks later by the circulatory system. The so called "secondary" pulmonary lesions which result from the bacillemia differ fundamentally from the primary lesions, in part, because the host has already developed a strong T cell mediated immunity when the hematogenous reseeding occurs. Secondary lung lesions in non-vaccinated guinea pigs behave similarly to primary lung lesions in previously vaccinated guinea pigs. Since the secondary, blood-borne lesions are thought to be the "reactivatable foci" which result in reactivation tuberculosis following prolonged persistent infection, it is important to understand the nature of the host-pathogen interaction in secondary lesions. The guinea pig model provides a unique opportunity to examine both the microbial and host factors which constitute that interface.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1472-9792
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-4
pubmed:dateRevised
2009-4-22
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Hematogenous reseeding of the lung in low-dose, aerosol-infected guinea pigs: unique features of the host-pathogen interface in secondary tubercles.
pubmed:affiliation
Department of Medical Microbiology and Immunology, Reynolds Medical Building, Texas A&M University System Health Science Center, Room 463, College Station, TX 77843-1114, USA. dmcmurray@tamu.edu
pubmed:publicationType
Journal Article, Review