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pubmed-article:12757503pubmed:abstractTextHepatitis B virus (HBV) may occasionally be transmitted through transfusion of blood units that are hepatitis B surface antigen (HBsAg) negative but HBV DNA positive. Children with beta-thalassemia are particularly susceptible to HBV because they receive multiple blood transfusions. These children have high infection rates despite vaccination against HBV. Post-vaccination infections may be a result of viruses harbouring surface (S)-gene mutations (e.g. G587A) in a region critical for reactivity to antibody to hepatitis B surface antigen (anti-HBs). The true prevalence of HBV in individuals with beta-thalassemia has not been studied previously.lld:pubmed
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pubmed-article:12757503pubmed:articleTitleHigh frequency of hepatitis B virus infection in patients with beta-thalassemia receiving multiple transfusions.lld:pubmed
pubmed-article:12757503pubmed:affiliationDepartment of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.lld:pubmed
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pubmed-article:12757503pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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