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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-6-11
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pubmed:abstractText |
Virtually all smooth muscle genes analyzed to date contain two or more essential binding sites for serum response factor (SRF) in their control regions. Because SRF is expressed in a wide range of cell types, it alone cannot account for smooth muscle-specific gene expression. We show that myocardin, a cardiac muscle- and smooth muscle-specific transcriptional coactivator of SRF, can activate smooth muscle gene expression in a variety of nonmuscle cell types via its association with SRF. Homodimerization of myocardin is required for maximal transcriptional activity and provides a mechanism for cooperative activation of smooth muscle genes by SRF-myocardin complexes bound to different SRF binding sites. These findings identify myocardin as a master regulator of smooth muscle gene expression and explain how SRF conveys smooth muscle specificity to its target genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-10205154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-10207131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-10694879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-10734136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-10983972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-11081517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-11285301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-11333224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-11439182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-11784081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-12215486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-12392995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-12397177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-12530967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-12640126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-12663482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-1333373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-2253873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-3203386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-3690668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-7588619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-7624392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-8065354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-9121477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-9242426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-943301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756293-9568714
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7129-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12756293-Amino Acid Sequence,
pubmed-meshheading:12756293-Animals,
pubmed-meshheading:12756293-Binding Sites,
pubmed-meshheading:12756293-Cell Line,
pubmed-meshheading:12756293-Cells, Cultured,
pubmed-meshheading:12756293-Dimerization,
pubmed-meshheading:12756293-Gene Expression Regulation, Developmental,
pubmed-meshheading:12756293-Mice,
pubmed-meshheading:12756293-Models, Biological,
pubmed-meshheading:12756293-Molecular Sequence Data,
pubmed-meshheading:12756293-Molecular Structure,
pubmed-meshheading:12756293-Muscle, Smooth,
pubmed-meshheading:12756293-Mutation,
pubmed-meshheading:12756293-Myocardium,
pubmed-meshheading:12756293-Nuclear Proteins,
pubmed-meshheading:12756293-Rats,
pubmed-meshheading:12756293-Serum Response Factor,
pubmed-meshheading:12756293-Trans-Activators
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pubmed:year |
2003
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pubmed:articleTitle |
Myocardin is a master regulator of smooth muscle gene expression.
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pubmed:affiliation |
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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