Linked Life Data

12756272

Source:http://linkedlifedata.com/resource/pubmed/id/12756272

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-5-20
pubmed:abstractText
Experimental allergic encephalomyelitis (EAE) is an animal model for multiple sclerosis induced by stimulating myelin basic protein (MBP)-specific T cells. The MBP-specific repertoire in B10.PL mice is shaped by tolerance mechanisms that eliminate MBP121-150-specific T cells. In contrast, MBPAc1-11-specific T cells escape tolerance and constitute the encephalitogenic repertoire. To determine if this differential tolerance is caused by differences in the abundance of MBP epitopes generated by processing, MBP peptides were eluted from I-Au complexes and analyzed by mass spectrometry. Peptides were identified from both the NH2-terminal and MBP121-150 regions. Unexpectedly, MBPAc1-18 and Ac1-17, which contain the MBPAc1-11 epitope, were much more abundant than MBP121-150 peptides. The results demonstrate that competition between two I-Au binding registers, a low affinity register defined by MBPAc1-11 and a high affinity register defined by MBP5-16, prevents most of the NH2-terminal naturally processed peptides from binding in the MBPAc1-11 register. The small fraction of MBPAc1-18 bound in the MBPAc1-11 register is not sufficient to induce tolerance but provides a ligand for MBPAc1-11-specific T cells during disease. These results provide a basis for both the lack of tolerance to MBPAc1-11 and the ability of this epitope to become a target during autoimmunity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-10352259, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-10775112, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-11008759, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-11336692, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-11466336, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-12150894, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-12190925, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-2188675, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-2431317, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-2480602, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-5806574, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-7520367, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-7679952, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-7694643, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-81270, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-8228814, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-8717508, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-8757949, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-9535647, http://linkedlifedata.com/resource/pubmed/commentcorrection/12756272-9620678
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
197
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1391-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity.
pubmed:affiliation
Department of Immunology, Box 357650, University of Washington, Seattle, WA 98195, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.