Linked Life Data

12754842

Source:http://linkedlifedata.com/resource/pubmed/id/12754842

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-5-20
pubmed:abstractText
The effects of haloperidol on retention of avoidance during its extinction in C57BL/6J mice were shown to depend on a behavioral stereotype (aggressive or submissive). In submissive mice, haloperidol (0.5 mg/kg) injected an hour before training stabilized retrieval of the conditioned reflex in repeated testings (up to 17 days) as compared to its fast extinction in control animals. In aggressive mice, on the contrary, haloperidol reduced the retention of the memory trace retrieval. It is suggested that divergent haloperidol effects on extinction of passive avoidance in mice with alternative behavioral strategies are determined by the features of organization of the mesolimbico-cortical dopaminergic system and emotional state, in particular, anxiety.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-4677
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Comparative analysis of haloperidol effects on passive avoidance retention in aggressive and submissive mice].
pubmed:affiliation
Institute of Physiology, Russian Academy of Medical Sciences, Siberian Division, Novosibirsk. dubrov@iph.ma.nsc.ru
pubmed:publicationType
Journal Article, Comparative Study, English Abstract