|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1976-8-2
|
|
pubmed:abstractText |
Concentrations of 6-beta-hydroxycortisol (6-OHF), a polar metabolite of cortisol formed in the endoplasmic reticulum (microsomes) of the liver, and 17-hydroxycorticosteroids (17-OHCS) were measured in the urines of six healthy adult male volunteers exposed to a mean of 9.6 MAC-hours of enflurane anesthesia as an index of possible enzyme induction. The ratio of 6-OHF to 17-OHCS in 24-hour urine specimens collected five days before anesthesia was compared with the ratio of these metabolites in 24-hour urine specimens collected 16 to 18 hours after anesthesia. The ratio of 6-OHF to 17-OHCS increased markedly in five and decreased slightly in one volunteer following anesthesia. The results indicate that enflurane may cause induction of hepatic microsomal enzymes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0003-3022
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
496-500
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1275317-17-Hydroxycorticosteroids,
pubmed-meshheading:1275317-Adult,
pubmed-meshheading:1275317-Anesthesia, Inhalation,
pubmed-meshheading:1275317-Enflurane,
pubmed-meshheading:1275317-Enzyme Induction,
pubmed-meshheading:1275317-Humans,
pubmed-meshheading:1275317-Hydrocortisone,
pubmed-meshheading:1275317-Liver,
pubmed-meshheading:1275317-Male,
pubmed-meshheading:1275317-Methyl Ethers,
pubmed-meshheading:1275317-Microsomes, Liver,
pubmed-meshheading:1275317-Tetrahydrocortisol,
pubmed-meshheading:1275317-Tetrahydrocortisone
|
|
pubmed:year |
1976
|
|
pubmed:articleTitle |
Enzyme induction by enflurane in man.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
