|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017129,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033684,
umls-concept:C0041904,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C1417166,
umls-concept:C1547699,
umls-concept:C2700640
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2003-5-19
|
|
pubmed:abstractText |
A division of labor exists between different classes of interstitial cells of Cajal (ICC) in the gastrointestinal tract. In the stomach and small intestine, ICC at the level of the myenteric plexus (IC-MY) act as slow wave pacemaker cells, whereas intramuscular ICC (IC-IM) in the stomach act as intermediaries in enteric motor neurotransmission. The muscle layers of the gastric fundus do not have IC-MY, therefore electric slow waves are not generated. Intramuscular ICC are absent in the gastric fundus of W/WV mutant mice, and excitatory and inhibitory motor nerve responses are reduced in these tissues. The absence of IC-IM in W/WV mutants in the fundus provides a unique opportunity to study the molecular changes that are associated with the loss of these cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0815-9319
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2003 Blackwell Publishing Asia Pty Ltd
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
712-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:12753155-Amino Acid Sequence,
pubmed-meshheading:12753155-Animals,
pubmed-meshheading:12753155-Blotting, Northern,
pubmed-meshheading:12753155-Cloning, Organism,
pubmed-meshheading:12753155-DNA, Complementary,
pubmed-meshheading:12753155-Expressed Sequence Tags,
pubmed-meshheading:12753155-Gastric Fundus,
pubmed-meshheading:12753155-Gene Expression Regulation,
pubmed-meshheading:12753155-Genetic Code,
pubmed-meshheading:12753155-Humans,
pubmed-meshheading:12753155-Male,
pubmed-meshheading:12753155-Mice,
pubmed-meshheading:12753155-Mice, Mutant Strains,
pubmed-meshheading:12753155-Models, Animal,
pubmed-meshheading:12753155-Molecular Sequence Data,
pubmed-meshheading:12753155-Myenteric Plexus,
pubmed-meshheading:12753155-Nerve Tissue Proteins,
pubmed-meshheading:12753155-Protein Array Analysis,
pubmed-meshheading:12753155-RNA, Messenger,
pubmed-meshheading:12753155-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12753155-Up-Regulation
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse.
|
|
pubmed:affiliation |
Department of Medicine, University of Yamanashi Medical School, Yamanashi, Japan.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
