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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5622
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pubmed:dateCreated |
2003-5-16
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pubmed:abstractText |
About 50% of cancer patients receive radiation therapy. Here we investigated the hypothesis that tumor response to radiation is determined not only by tumor cell phenotype but also by microvascular sensitivity. MCA/129 fibrosarcomas and B16F1 melanomas grown in apoptosis-resistant acid sphingomyelinase (asmase)-deficient or Bax-deficient mice displayed markedly reduced baseline microvascular endothelial apoptosis and grew 200 to 400% faster than tumors on wild-type microvasculature. Thus, endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth. Moreover, these tumors exhibited reduced endothelial apoptosis upon irradiation and, unlike tumors in wild-type mice, they were resistant to single-dose radiation up to 20 grays (Gy). These studies indicate that microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1155-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12750523-Animals,
pubmed-meshheading:12750523-Apoptosis,
pubmed-meshheading:12750523-Bone Marrow Transplantation,
pubmed-meshheading:12750523-Disease Models, Animal,
pubmed-meshheading:12750523-Endothelium, Vascular,
pubmed-meshheading:12750523-Fibrosarcoma,
pubmed-meshheading:12750523-In Situ Nick-End Labeling,
pubmed-meshheading:12750523-Melanoma, Experimental,
pubmed-meshheading:12750523-Mice,
pubmed-meshheading:12750523-Neoplasm Transplantation,
pubmed-meshheading:12750523-Neovascularization, Pathologic,
pubmed-meshheading:12750523-Proto-Oncogene Proteins,
pubmed-meshheading:12750523-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12750523-Radiation Tolerance,
pubmed-meshheading:12750523-Sphingomyelin Phosphodiesterase,
pubmed-meshheading:12750523-bcl-2-Associated X Protein
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pubmed:year |
2003
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pubmed:articleTitle |
Tumor response to radiotherapy regulated by endothelial cell apoptosis.
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pubmed:affiliation |
Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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