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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-5-16
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pubmed:abstractText |
The absence of immune defects that occurs in the syndrome of long-term nonprogressive (LTNP) HIV infection offers insights into the pathophysiology of HIV-induced immune disease. The (H[F/S]RIG)(2) domain of viral protein R (Vpr) induces apoptosis and may contribute to HIV-induced T cell depletion. We demonstrate a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive disease. In addition, T cell infections using vesicular stomatitis virus G (VSV-G) pseudotyped HIV-1 Vpr R77Q result in less (P = 0.01) T cell death than infections using wild-type Vpr, despite similar levels of viral replication. Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential (deltapsi(m)), and DNA fragmentation factor activation are attenuated by R77Q Vpr. These data highlight the pathophysiologic role of Vpr in HIV-induced immune disease and suggest a novel mechanism of LTNP.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-10381636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-10397332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-10620603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-10708055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-11000244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-11049971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-11136258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-11181702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-11437653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-11493454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-12750393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-16465294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-1702216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-7481804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-7682710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-7708721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-7937784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-7971975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-7986410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-8597949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-8806556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9123841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9188632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9294127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9384300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9400591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9573232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9579602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9649560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12750404-9728534
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:BadleyAndrew DAD,
pubmed-author:ChenZhaoxiaZ,
pubmed-author:CohenEric AEA,
pubmed-author:CohenOren JOJ,
pubmed-author:GomezTimothy STS,
pubmed-author:HawleyNanciN,
pubmed-author:KimJohn EJE,
pubmed-author:LumJulian JJJ,
pubmed-author:LynchDavidD,
pubmed-author:MontpetitMichaelM,
pubmed-author:NieZilinZ,
pubmed-author:PilonAndré AAA,
pubmed-author:Sanchez-DardonJaimeJ,
pubmed-author:WeaverJoel GJG,
pubmed-author:YaoXiao-JianXJ
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1547-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12750404-Amino Acid Substitution,
pubmed-meshheading:12750404-Apoptosis,
pubmed-meshheading:12750404-CD4 Lymphocyte Count,
pubmed-meshheading:12750404-Caspases,
pubmed-meshheading:12750404-Cell Survival,
pubmed-meshheading:12750404-Disease Progression,
pubmed-meshheading:12750404-Dose-Response Relationship, Drug,
pubmed-meshheading:12750404-Gene Frequency,
pubmed-meshheading:12750404-Gene Products, vpr,
pubmed-meshheading:12750404-HIV Infections,
pubmed-meshheading:12750404-HIV Long-Term Survivors,
pubmed-meshheading:12750404-HIV-1,
pubmed-meshheading:12750404-Humans,
pubmed-meshheading:12750404-Jurkat Cells,
pubmed-meshheading:12750404-Mitochondria,
pubmed-meshheading:12750404-Mutation,
pubmed-meshheading:12750404-Peptide Fragments,
pubmed-meshheading:12750404-T-Lymphocytes,
pubmed-meshheading:12750404-Vesicular stomatitis Indiana virus,
pubmed-meshheading:12750404-vpr Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2003
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pubmed:articleTitle |
Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.
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pubmed:affiliation |
Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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