| pubmed-article:12750294 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12750294 | lifeskim:mentions | umls-concept:C0042666 | lld:lifeskim |
| pubmed-article:12750294 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:12750294 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:12750294 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:12750294 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12750294 | pubmed:dateCreated | 2003-5-16 | lld:pubmed |
| pubmed-article:12750294 | pubmed:abstractText | The cytoplasmic and nuclear redistribution of beta-catenin and the de novo expression of vimentin are frequently involved in the epithelial-to-mesenchymal transition associated with increased invasive/migratory properties of epithelial cells. Because beta-catenin can act as a coactivator of transcription through its binding to the T-cell factor (TCF)/lymphoid enhancer factor 1 transcription factor family, we have explored the possibility that beta-catenin/TCF could directly transactivate vimentin. We first compared vimentin expression in relation with the localization of beta-catenin in eight breast cancer cell lines displaying various degrees of invasiveness and in a model of cell migration using human mammary MCF10A cells. We could thus show a cytoplasmic and/or nuclear distribution of beta-catenin in invasive/migratory cells expressing vimentin, but not in noninvasive/stationary vimentin-negative cell lines. In addition, the human vimentin promoter was found to be up-regulated by beta-catenin and TCF-4 cotransfection. Varying with the cellular background, a diminution of this up-regulation was observed when the putative beta-catenin/TCF binding site of the vimentin promoter was mutated. Our results therefore demonstrate that the vimentin promoter is a target of the beta-catenin/TCF pathway and strongly suggest an implication of this regulation in epithelial cell migration/invasion. | lld:pubmed |
| pubmed-article:12750294 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12750294 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12750294 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12750294 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12750294 | pubmed:month | May | lld:pubmed |
| pubmed-article:12750294 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:FoidartJean-M... | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:BirembautPhil... | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:PoletteMyriam... | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:Nawrocki-Raby... | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:GillesChristi... | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:MestdagtMélan... | lld:pubmed |
| pubmed-article:12750294 | pubmed:author | pubmed-author:RuggeriPhilip... | lld:pubmed |
| pubmed-article:12750294 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12750294 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12750294 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12750294 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12750294 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12750294 | pubmed:pagination | 2658-64 | lld:pubmed |
| pubmed-article:12750294 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12750294 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12750294 | pubmed:articleTitle | Transactivation of vimentin by beta-catenin in human breast cancer cells. | lld:pubmed |
| pubmed-article:12750294 | pubmed:affiliation | Laboratory of Tumor and Developmental Biology, University of Liège, CHU Sart-Tilman, B23, B-4000 Liège, Belgium. cgilles@ulg.ac.be | lld:pubmed |
| pubmed-article:12750294 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12750294 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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